66730-27-6Relevant academic research and scientific papers
Peroxidation of C-H bonds adjacent to an amide nitrogen atom under mild conditions
Yu, Hui,Shen, Jie
supporting information, p. 3204 - 3207 (2014/07/08)
Under mild conditions, the oxidative functionalization of C-H bonds adjacent to an amide nitrogen atom was achieved. tert-Butylperoxyamido acetal was obtained in high yields and could be further converted into α-substituted amides by treatment with Grigna
Carbon-carbon bond formations at the benzylic positions of N-benzylxanthone imines and N-benzyldi-1-naphthyl ketone imine
Niwa, Takashi,Suehiro, Takafumi,Yorimitsu, Hideki,Oshima, Koichiro
experimental part, p. 5125 - 5131 (2009/11/30)
Two N-benzyl imines are designed to allow for carbon-carbon bond formations at the aminated benzylic positions. Direct benzylic arylation reactions of N-benzylxanthone imine with aryl chlorides proceed under palladium catalysis in the presence of cesium hydroxide, yielding the corresponding benzhydrylamine derivatives. Alkylation reactions of N-benzyldi-1-naphthyl ketone imine with alkyl halides in the presence of potassium tert-butoxide afford the corresponding 1-phenylalkylamines in high yields. Conjugate addition of N-benzyldi-1-naphthyl ketone imine is also described.
A Conceptually New Approach to the Synthesis of Secondary Amides and Thioamides
Katritzky, Alan R.,Drewniak, Malgorzata,Lue, Ping
, p. 5854 - 5856 (2007/10/02)
Amides and thioamides of type RC(=X)NHCHR1R2 are prepared in high yield with the formation of a new C-R2 bond by the action of a Grignard reagent (R2MgX) on the readily available adducts from an amide RCONH2 (or thioamide RCSNH2), aldehyde R1CHO, and benzotriazole.
