66737-86-8

Usage

InChI:InChI=1/C22H26O2/c1-21(2,3)15-12-16-18(14-10-8-7-9-11-14)20(23)24-19(16)17(13-15)22(4,5)6/h7-13,18H,1-6H3

Upstream product

• 163489-63-2 5,7-di-tert-butyl-3-hydroxy-3H-benzofuran-2-one 
• 71-43-2 benzene 
• 387365-63-1 2-amino-3-phenyl-5,7-di-tert-butylbenzofuran 
• 96-76-4 2,4-di-tert-Butylphenol 
• 611-71-2 MANDELIC ACID 
• 252961-11-8 2,4-di-tert-butyl-6-(dimethylamino-phenyl-methyl)-phenol 
• 100-52-7 benzaldehyde 

Downstream Products

• 24242-58-8 (3,5-di-tert-butyl-2-hydroxyphenyl)(phenyl)methanone 

Relevant academic research and scientific papers

Selective Transformation of Vicinal Glycols to α-Hydroxy Acetates in Water via a Dehydrogenation and Oxidization Relay Process by a Self-Supported Single-Site Iridium Catalyst

α-Hydroxy acids have attracted broad attention because of their prevalence in bioactive molecules and biodegradable polymers, but their conventional syntheses are usually restricted to aromatic substrates, especially, in a stepwise manner. Herein, we disclose the transformation of alkyl and aryl vicinal glycols to α-hydroxy acetates in water under the air atmosphere with our solid self-supported NHC-Ir single-site catalyst. Both aliphatic and aromatic glycols are compatible with a much higher catalytic efficiency in the presence of this solid single-site catalyst than other viable molecular catalysts (93% vs a dehydrogenation facilitated by the catalyst, and then it proceeds through an unexpected oxidization relay step by oxygen in the air, leading to the α-hydroxy acetate formation. Our protocol can potentially contribute to the valorization of readily available and inexpensive diols.

A Concise Route to 2-Amino-3-aryl-3H-benzofurans and their Use as Precursors to 3-Aryl-3H-benzofuran-2-one and 1H-Benzofuro[2,3-￡]pyridin-2- one Derivatives

A concise approach to 2-amino-3-aryl-3H-benzofurans based on the Michael addition of NaCN onto in situ generated substituted o-quinone methides has been developed. Straightforward access to 3-aryl-3H-benzofuran-2-ones was achieved upon acidic hydrolysis whereas JV-Boc-protected 2-amino-3-aryl-3H-benzofurans underwent smooth intramolecular cyclisation to give 1H-benzofuro[2,3-b]pyridin- 2-one derivatives.

Process for the preparation of 3-aryl-benzofuranones

Process for the preparation of compounds of formula (I), wherein the general symbols are as defined in claim1, which process comprises reacting a compound of formula (V), wherein the general symbols are as defined in claim1, with carbon monoxide in the presence of a catalyst.

Process for the preparation of 3-aryl-benzofuran-2-ones

The instant invention discloses a process for the preparation of compounds of formula I wherein the general symbols are as defined in claim 1, which process comprises hydrolyzing a compound of formula V wherein the general symbols are as defined in claim 1, in an aqueous solvent in the presence of an acid. The compounds of the formula V are new and useful as stabilizers for protecting organic materials, in particular polymers and lubricants, against oxidative, thermal or light-induced degradation.

Process for the preparation of 3-aryl-benzofuran-2-ones

The instant invention discloses a process for the preparation of compounds of formula I wherein the general symbols are as defined in claim 1, which process comprises hydrolyzing a compound of formula V wherein the general symbols are as defined in claim 1, in an aqueous solvent in the presence of an acid. The compounds of the formula V are new and useful as stabilizers for protecting organic materials, in particular polymers and lubricants, against oxidative, thermal or light-induced degradation.

A versatile new synthesis of 3-aryl-3H-benzofuran-2-ones

Aromatic or heteroaromatic hydrocarbons are easily alkylated with 3- hydroxy-3H-benzofuran-2-ones under Friedel-Crafts or acid catalysis to afford 3-aryl-3H-benzofuran-2-ones in good yield. Access to the starting 3-hydroxy- 3H-benzofuran-2-ones is easily achievable by reaction of suitably substituted phenols with glyoxylic acid.

Process for the preparation of 3-arylbenzofuranones

A process for the preparation of compounds of formula I STR1 wherein the general symbols are as defined in claim 1, which comprises reacting a compound of formula III STR2 wherein the general symbols are as defined in claim 1, with a compound of formula IV