66739-85-3Relevant academic research and scientific papers
Amine compound inhibiting SSAO/VAP-1 and application thereof in medicine
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Paragraph 0688; 0689; 0693; 0694, (2019/02/04)
The invention relates to an amine compound for inhibiting semicarbazide-sensitive amine oxidase (SSAO) and/or vascular adhesion protein 1 (VAP-1) and medicinal application thereof, and further relatesto a pharmaceutical composition containing the compound
Synthesis of Complex Phenols Enabled by a Rationally Designed Hydroxide Surrogate
Fier, Patrick S.,Maloney, Kevin M.
supporting information, p. 4478 - 4482 (2017/04/13)
The conversion of aryl halides to phenols under mild reaction conditions is a longstanding and formidable challenge in organic chemistry. Herein, we report the rational design of a broadly applicable Pd-catalyzed method to prepare phenols with benzaldehyde oxime as a hydroxide surrogate. These reactions occur under mildly basic conditions and enable the late-stage hydroxylation of several functionally-dense drug-like aryl halides.
Reagent Design and Ligand Evolution for the Development of a Mild Copper-Catalyzed Hydroxylation Reaction
Fier, Patrick S.,Maloney, Kevin M.
supporting information, p. 3033 - 3036 (2017/06/07)
Parallel synthesis and mass-directed purification of a modular ligand library, high-throughput experimentation, and rational ligand evolution have led to a novel copper catalyst for the synthesis of phenols with a traceless hydroxide surrogate. The mild reaction conditions reported here enable the late-stage synthesis of numerous complex, druglike phenols.
SELECTIVE ACID HYDROLYSIS OF 2-SUBSTITUTED-5-DIMETHYLAMINOMETHYLENEAMINOPYRIMIDINES TO 5-AMINO- AND 5-HYDROXYPYRIMIDINES
Kizner, T. A.,Mikhaleva, M. A.,Serebryakova, E. S.
, p. 668 - 670 (2007/10/02)
Conditions are described for the selective acid hydrolysis of 2-substituted-5-dimethylaminomethyleneaminopyrimidines in 0.2-2 M sulfuric acid, to give high yields of the corresponding 5-amino- and difficultly accessible 5-hydroxypyrimidines.
UV SPECTROSCOPIC STUDY OF THE ACID-BASE REACTIONS OF 3-HYDROXYPYRIDINES AND 5-HYDROXYPYRIMIDINES
Korobeinicheva, I. K.,Sedova, V. F.,Gashev, S. B.,Smirnov, L. D.,Yagodina, O. V.,Mamaev, V. P.
, p. 913 - 919 (2007/10/02)
The acid-base equilibrium behavior of alkyl(phenyl)-substituted 3-hydroxypyridines and 5-hydroxypyrimidines, and their dependence on pH values in aqueous solution, on the solvent, and on the phase composition, have been studied using UV spectroscopy.It has been found that in neutral aqueous solution all of the substituted 3-hydroxypyridines examined contain, in addition to the neutral form, a bipolar form, whose concentration depends on the nature and position of the substituent.In contrast, methyl substituted 5-hydroxypyrimidines form significant amounts of the bipolar form only in more acidic media.
