6674-40-4

Usage

Uses

Used in Pharmaceutical Industry:
5-Hydroxy-7-acetoxyflavone is used as a bioactive compound for its potential therapeutic applications due to its antioxidant, anti-inflammatory, and anticancer properties. Its presence in traditional Chinese medicine suggests a long history of use, and modern research aims to validate and expand upon these traditional uses.
Used in Nutraceutical Industry:
In the nutraceutical industry, 5-Hydroxy-7-acetoxyflavone is utilized as a dietary supplement ingredient, capitalizing on its antioxidant properties to support overall health and well-being. Its potential to reduce inflammation and combat oxidative stress contributes to its value in this application.
Used in Cosmetic Industry:
5-Hydroxy-7-acetoxyflavone is employed in cosmetic formulations for its antioxidant and anti-inflammatory effects, which can help protect the skin from environmental stressors and promote a healthier, more youthful appearance.
Used in Research and Development:
In the field of research and development, 5-Hydroxy-7-acetoxyflavone serves as a subject for scientific investigation to explore its potential mechanisms of action and therapeutic applications further. This includes studies on its effects on various diseases and conditions, as well as its interactions with other bioactive compounds.
Used in Functional Food Industry:
5-Hydroxy-7-acetoxyflavone is incorporated into functional food products to enhance their health benefits. Its antioxidant and anti-inflammatory properties can contribute to the development of foods with added health-promoting qualities, targeting consumers interested in maintaining or improving their health through diet.

Upstream product

• 480-40-0 5,7-dihydroxy-2-phenyl-chromen-4-one 
• 108-24-7 acetic anhydride 

Downstream Products

• 539823-65-9 acetic acid 5-hydroxy-6,8-diiodo-4-oxo-2-phenyl-4H-chromen-7-yl ester 
• 1329-10-8 toringin 
• 1265223-26-4 7-acetoxy-5-methoxyflavone 
• 520-28-5 tectochrysine 
• 21392-57-4 Dimethyl-chrysin 
• 23296-91-5 5-acetoxy-7-methoxyflavone 
• 4431-47-4 5,8-dihydroxy-7-methoxyflavone 
• 29550-13-8 5,6-dihydroxy-7-methoxyflavone 
• 89971-03-9 7-methoxy-2-phenyl-4H-1-benzopyran-4,5,8-trione 
• 1265223-36-6 C₁₈H₁₄O₆ 
• 1265223-29-7 4,6-dimethoxy-1aphenyl-1aH-oxireno[2,3-b]chromen-7(7aH)-one 
• 119892-40-9 6-hydroxy-5,7-dimethoxyflavone 
• 89971-04-0 8-hydroxy-5,7-dimethoxyflavone 

Relevant academic research and scientific papers

Flavonoid-based inhibitors of the Phi-class glutathione transferase from black-grass to combat multiple herbicide resistance

The evolution and growth of multiple-herbicide resistance (MHR) in grass weeds continues to threaten global cereal production. While various processes can contribute to resistance, earlier work has identified the phi class glutathione-S-transferase (AmGSTF1) as a functional biomarker of MHR in black-grass (Alopecurus myosuroides). This study provides further insights into the role of AmGSTF1 in MHR using a combination of chemical and structural biology. Crystal structures of wild-type AmGSTF1, together with two specifically designed variants that allowed the co-crystal structure determination with glutathione and a glutathione adduct of the AmGSTF1 inhibitor 4-chloro-7-nitro-benzofurazan (NBD-Cl) were obtained. These studies demonstrated that the inhibitory activity of NBD-Cl was associated with the occlusion of the active site and the impediment of substrate binding. A search for other selective inhibitors of AmGSTF1, using ligand-fishing experiments, identified a number of flavonoids as potential ligands. Subsequent experiments using black-grass extracts discovered a specific flavonoid as a natural ligand of the recombinant enzyme. A series of related synthetic flavonoids was prepared and their binding to AmGSTF1 was investigated showing a high affinity for derivatives bearing a O-5-decyl-α-carboxylate. Molecular modelling based on high-resolution crystal structures allowed a binding pose to be defined which explained flavonoid binding specificity. Crucially, high binding affinity was linked to a reversal of the herbicide resistance phenotype in MHR black-grass. Collectively, these results present a nature-inspired new lead for the development of herbicide synergists to counteract MHR in weeds. This journal is

PHARMACEUTICAL COMPOSITION FOR PREVENTING OR TREATING DIABETES COMPLICATIONS COMPRISING NOVEL CHRYSIN DERIVATIVE COMPOUND AS ACTIVE INGREDIENT

Disclosed is a pharmaceutical composition for preventing or treating diabetes complications containing a novel chrysin derivative compound as an active ingredient, and more specifically, a pharmaceutical composition for preventing or treating diabetes complications containing, as an active ingredient, a novel chrysin derivative compound that is capable of preventing or treating diabetes complications due to the ability thereof to inhibit the formation of an advanced glycation end-product (AGE).

Anti-glycation, carbonyl trapping and anti-inflammatory activities of chrysin derivatives

The aim of this study was searching anti-glycation, carbonyl trapping and anti-inflammatory activities of chrysin derivatives. The inhibitory effect of chrysin on advanced glycation end-products (AGEs) was investigated by trapping methylglyoxal (MGO), and MGO-conjugated adducts of chrysin were analyzed using LC-MS/MS. The mono- or di-MGO-conjugated adducts of chrysin were present at 63.86 and 29.69% upon 48 h of incubation at a chrysin:MGO ratio of 1:10. The MGO adducted positions on chrysin were at carbon 6 or 6 & 8 in the A ring by classic aldol condensation. To provide applicable knowledge for developing chrysin derivatives as AGE inhibitors, we synthesized several O-alkyl or ester derivatives of chrysin and compared their AGE formation inhibitory, anti-inflammatory, and water solubility characteristics. The results showed that 5,7-di-O-acetylchrysin possessed higher AGE inhibitory and water solubility qualities than original chrysin, and retained the anti-inflammation activity. These results suggested that 5,7-di-O-acetylchrysin could be a potent functional food ingredient as an AGE inhibitor and anti-inflammatory agent, and promotes the development of the use of chrysin in functional foods.

Synthesis and antitumor activity evaluation of chrysin derivatives

A series of 5,7-disubstituted chrysin, 7-monosubstituted chrysin, 5-monosubstituted chrysin derivatives were synthesized by alkylation, acetylation, benzoylation, carboxymethylation, and evaluated on their antitumor activity of H22 cells in the search for potential antitumor agents. Among them, compound 3 (5,7-diacetyl chrysin) displayed the most potent antitumor activity with IC50 value of 141 μM. Moreover, there is significant up-regulation of G2 in cell cycle of H22.

Synthesis and anticancer effect of chrysin derivatives

A series of chrysin derivatives, prepared by alkylation, halogenation, nitration, methylation, acetylation and trifluoromethylation, were tested in vitro against human gastric adenocarcinoma cell line (SGC-7901) and colorectal adenocarcinoma (HT-29) cells. Among these derivatives of chrysin, 5,7-dimethoxy-8-iodochrysin 3 and 8-bromo-5-hydroxy-7-methoxychrysin 11 have the strongest activities against SGC-7901 and HT-29 cells, respectively. 5,7-Dihydroxy-8-nitrochrysin 12 were found to have strong activities against both SGC-7901 and HT-29 cells.