667433-79-6

Upstream product

• 2039-67-0 2-(3-methoxyphenyl)-1-ethanamine 
• 3179-09-7 1-methoxy-3-(2-nitrovinyl)benzene 
• 591-31-1 3-methoxy-benzaldehyde 
• 136918-14-4 phthalimide 
• 5000-65-7 2-bromo-3'-methoxyacetophenone 
• 1074-82-4 potassium phtalimide 

Downstream Products

• 106191-59-7 β-methylene-β-(3-methoxyphenyl)ethanamine 
• 1286255-65-9 4-bromo-N-[2-(3-methoxyphenyl)allyl]benzamide 
• 1286255-70-6 (R)-2-(4-bromophenyl)-5-(chloromethyl)-5-(3-methoxyphenyl)-4,5-dihydrooxazole 
• 85278-39-3 2-(2-(3-methoxyphenyl)allyl)isoindoline-1,3-dione 

Relevant academic research and scientific papers

Combined Photoredox/Enzymatic C?H Benzylic Hydroxylations

Chemical transformations that install heteroatoms into C?H bonds are of significant interest because they streamline the construction of value-added small molecules. Direct C?H oxyfunctionalization, or the one step conversion of a C?H bond to a C?O bond, could be a highly enabling transformation due to the prevalence of the resulting enantioenriched alcohols in pharmaceuticals and natural products,. Here we report a single-flask photoredox/enzymatic process for direct C?H hydroxylation that proceeds with broad reactivity, chemoselectivity and enantioselectivity. This unified strategy advances general photoredox and enzymatic catalysis synergy and enables chemoenzymatic processes for powerful and selective oxidative transformations.

Palladium-catalyzed asymmetric hydrogenation of functionalized ketones

(Chemical Equation Presented) A novel catalytic system for asymmetric hydrogenation of functionalized ketones has been developed using a Pd/bisphosphine complex as the catalyst in 2,2,2-trifluoroethanol. The reaction exhibits high enantioselectivity, and

Highly Enantioselective Asymmetric Hydrogenation of α-Phthalimide Ketone: An Efficient Entry to Enantiomerically Pure Amino Alcohols

A new type of α-phthalimide ketones was hydrogenated in excellent enantioselectivity by using a Ru-(C3-TunePhos) complex as the catalyst. Up to 10000 turnovers have been achieved in more than 99% ee in the hydrogenation reaction. A dynamic kinetic resolution study for the synthesis of threonine was performed, and high anti selectivity (>97:3) was observed for the first time. An efficient method to synthesize enantiomerically pure amino alcohols has been developed. Copyright