667461-56-5

Basic information

• Product Name: 5H-1,3-Dioxolo[4,5-c]pyrrole-5-ethanol,tetrahydro-,(3aR,6aS)-(9CI)
• Synonyms: 5H-1,3-Dioxolo[4,5-c]pyrrole-5-ethanol,tetrahydro-,(3aR,6aS)-(9CI)
• CAS NO: 667461-56-5
• Molecular Formula: C7H13NO3
• Molecular Weight: 159.18
• Product Categories: AMINETERTIARY
• Mol File: 667461-56-5.mol
• Article Data: 1

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 5H-1,3-Dioxolo[4,5-c]pyrrole-5-ethanol,tetrahydro-,(3aR,6aS)-(9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: 5H-1,3-Dioxolo[4,5-c]pyrrole-5-ethanol,tetrahydro-,(3aR,6aS)-(9CI)(667461-56-5)
• EPA Substance Registry System: 5H-1,3-Dioxolo[4,5-c]pyrrole-5-ethanol,tetrahydro-,(3aR,6aS)-(9CI)(667461-56-5)

Safety Data

• Hazardous Substances Data: 667461-56-5(Hazardous Substances Data)

Upstream product

• 692058-52-9 (3aR,6aS)-tetrahydro-3aH-[1,3]dioxolo[4,5-c]pyrrole hydrochloride 
• 540-51-2 2-bromoethanol 

Relevant articles and documents

QUINAZOLINE DERIVATIVES AS INHIBITORS OF VEGF RECEPTOR TYROSINE KINASES

The present invention relates to compounds of the Formula (I): wherein Z is -NH-, -O- or -S-; R 1 represents bromo or chloro; R 3 represents C 1-3 alkoxy or hydrogen; R 2 is selected from one of the following three groups: (i) Q 1 X 1 - wherein X 1 and Q 1 are as defined herein; (ii) Q 15 W 3 - wherein Q 15 and W 3 are as defined herein; and (iii) Q 21 W 4 C 1-5 alkylX 1 wherein X 1 , W 4 and Q 21 are as defined herein; and salts thereof; their use in the manufacture of a medicament for use in the production of an antiangiogenic and/or vascular permeability reducing effect in warm blooded animals; processes for the preparation of such compounds; pharmaceutical compositions containing a compound of formula (I) or a pharmaceutically acceptable salt thereof and methods of treating disease states involving angiogenesis by administering a compound of formula (I) or a pharmaceutically acceptable salt thereof. The compounds of formula (I) inhibit the effects of VEGF, a property of value in the treatment of a number of disease states including cancer and rheumatoid arthritis.