66751-31-3 Usage
General Description
1-Benzyl-6-hydroxy-7-cyano-5-azaindolin, also known as sunitinib, is a chemical compound used as a targeted cancer therapy. It inhibits multiple receptor tyrosine kinases, including vascular endothelial growth factor receptor (VEGFR) and platelet-derived growth factor receptor (PDGFR), that are involved in tumor growth and angiogenesis. Sunitinib has been approved for the treatment of various types of cancer, including gastrointestinal stromal tumors (GIST), advanced renal cell carcinoma, and pancreatic neuroendocrine tumors. It is typically administered orally in the form of a capsule or tablet and has been shown to be effective in extending the survival of patients with these types of cancer. However, sunitinib can cause side effects such as fatigue, diarrhea, nausea, and hypertension. Therefore, it is important for patients to be closely monitored while taking this medication.
Check Digit Verification of cas no
The CAS Registry Mumber 66751-31-3 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 6,6,7,5 and 1 respectively; the second part has 2 digits, 3 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 66751-31:
(7*6)+(6*6)+(5*7)+(4*5)+(3*1)+(2*3)+(1*1)=143
143 % 10 = 3
So 66751-31-3 is a valid CAS Registry Number.
66751-31-3Relevant academic research and scientific papers
AZAINDOLE DERIVATIVES. 60. NUCLEOPHILIC SUBSTITUTION REACTIONS IN 6-CHLORO-5-AZAINDOLINES
Azimov, V. A.,Bychikhina, N. N.,Yakhontov, L. N.
, p. 1208 - 1213 (2007/10/02)
Reactions involving nucleophilic substitution of the halogen atoms in 1-benzyl-6-chloro-7-cyano-5-azaindoline by alkoxy groups and residues of varios amines were investigated.The effect of electron acceptor substituents on the saponification of the alkoxy
