6678-86-0

Basic information

• Product Name: 1-ETHYL-2,3,4,9-TETRAHYDRO-1H-BETA-CARBOLINE
• Synonyms: 1-Ethyl-1,2,3,4-tetrahydro-9H-pyrido[3,4-b]indole;1-Ethyl-1,2,3,4-tetrahydro-β-carboline;1-Ethyl-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole
• CAS NO: 6678-86-0
• Molecular Formula: C₁₃H₁₆N₂
• Molecular Weight: 200.2859
• Mol File: 6678-86-0.mol
• Article Data: 17

Chemical Properties

• Boiling Point: 373.7°C at 760 mmHg
• Flash Point: 179.8°C
• Appearance: /
• Density: 1.098g/cm³
• Vapor Pressure: 8.82E-06mmHg at 25°C
• Refractive Index: 1.612
• CAS DataBase Reference: 1-ETHYL-2,3,4,9-TETRAHYDRO-1H-BETA-CARBOLINE(CAS DataBase Reference)
• NIST Chemistry Reference: 1-ETHYL-2,3,4,9-TETRAHYDRO-1H-BETA-CARBOLINE(6678-86-0)
• EPA Substance Registry System: 1-ETHYL-2,3,4,9-TETRAHYDRO-1H-BETA-CARBOLINE(6678-86-0)

Safety Data

• Statements: 36/37/38
• Safety Statements: 26-36/37/39
• Hazardous Substances Data: 6678-86-0(Hazardous Substances Data)

Usage

General Description

1-Ethyl-2,3,4,9-tetrahydro-1H-beta-carboline, also known as norharmane, is a heterocyclic compound that belongs to the beta-carboline family. It is found in various plants such as tobacco and coffee and also occurs as a natural product in human urine. 1-ETHYL-2,3,4,9-TETRAHYDRO-1H-BETA-CARBOLINE has been investigated for its potential psychotropic effects, and it has been suggested to interact with neurotransmitter systems in the brain. 1-Ethyl-2,3,4,9-tetrahydro-1H-beta-carboline has also been studied for its potential role in the formation of DNA adducts, which could have implications for cancer development. Overall, this compound is of interest to researchers for its possible effects on the central nervous system and its potential role in biological processes.

InChI:InChI=1/C13H16N2/c1-2-11-13-10(7-8-14-11)9-5-3-4-6-12(9)15-13/h3-6,11,14-15H,2,7-8H2,1H3

Upstream product

• 61-54-1 tryptamine 
• 123-38-6 propionaldehyde 
• 123-72-8 butyraldehyde 
• 65601-07-2 1-Ethyl-4,9-dihydro-3H-pyrido<3,4-b>indole 
• 343-94-2 tryptamine hydochloride 

Downstream Products

• 75304-06-2 1-ethyl-2-benzoyl-1,2,3,4-tetrahydro-9H-pyrido<3,4-b>indole 
• 1373764-81-8 1-ethyl-N-phenylacetyl-1,3,4,9-tetrahydro-β-carboline 
• 20127-61-1 1-ethyl-9H-β-carboline 
• 26585-14-8 crenatine 
• 75314-80-6 2-Benzoyl-1-ethyl-1,2,3,9-tetrahydro-β-carbolin-4-one 
• 75304-07-3 N-[2-(2-Propionyl-1H-indol-3-yl)-ethyl]-benzamide 

Relevant articles and documents

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Candida antarctica lipase B catalysed kinetic resolution of 1,2,3,4-tetrahydro-?-carbolines: Substrate specificity

In the frame of substrate specificity, CAL-B-catalysed asymmetric N-alkoxycarbonylations of 1-substituted tetrahydro-?-carbolines (Me, Et, Pr, iPr) have been studied. High enantioselectivities (>200) were observed, when alkoxycarbonylation of racemic compounds (±)-1,3,5,7 were performed in DIPE in the presence of phenyl allyl carbonate and Et3N at 60 °C using ultrasound shaking method. The reaction time increased considerably with increasing substituent size on C1; however, the isopropyl-substituted compound proved to be too bulky for the optimum activity of CAL-B. The (R)-carbamate enantiomers were hydrolysed using Pd2(dba)3.CHCl3 and the enantiomers of the free amines were obtained with excellent ee (>99%).

AGENTS FOR DIFFERENTIATING STEM CELLS AND TREATING CANCER

The present application discloses a method for identifying an agent for the treatment or prevention of cancer or metastatic cancer comprising the steps of contacting stem cell with a potential agent, and identifying an agent that induces differentiation, or inhibits stem cell pluripotency or growth of the stem cell, wherein such agent is determined to be an anti-cancer agent.