66781-19-9

Upstream product

• 556-52-5 oxiranyl-methanol 
• 120-20-7 2-(3,4-dimethoxyphenyl)-ethylamine 

Downstream Products

• 83231-40-7 4-Hydroxymethyl-benzoic acid 3-[2-(3,4-dimethoxy-phenyl)-ethylamino]-2-hydroxy-propyl ester 
• 83230-95-9 3-Chloro-benzoic acid 3-[2-(3,4-dimethoxy-phenyl)-ethylamino]-2-hydroxy-propyl ester 
• 66781-20-2 (S) 2-phenyl-3-[2-(3,4-dimethoxyphenyl)ethyl]-5-hydroxymethyloxazolidine 
• 83230-93-7 2-Methyl-benzoic acid 3-[2-(3,4-dimethoxy-phenyl)-ethylamino]-2-hydroxy-propyl ester 
• 90531-65-0 4-Amino-benzoic acid 3-[2-(3,4-dimethoxy-phenyl)-ethylamino]-2-hydroxy-propyl ester 
• 83230-98-2 3-Fluoro-benzoic acid 3-[2-(3,4-dimethoxy-phenyl)-ethylamino]-2-hydroxy-propyl ester 
• 90531-61-6 2-Fluoro-benzoic acid 3-[2-(3,4-dimethoxy-phenyl)-ethylamino]-2-hydroxy-propyl ester 
• 85613-56-5 1-[2-(3,4-Dimethoxy-phenyl)-ethylamino]-3-[4-(5-methyl-1H-imidazol-2-yl)-phenoxy]-propan-2-ol 
• 91944-25-1 1-[2-(3,4-Dimethoxy-phenyl)-ethylamino]-3-[4-(5-thiophen-2-yl-1H-imidazol-2-yl)-phenoxy]-propan-2-ol 
• 85613-47-4 2-phenyl-3-<2-(3,4-dimethoxyphenyl)ethyl>-5-(hydroxymethyl)oxazolidine p-toluenesulfonate 
• 71813-71-3 4-[3-(3,4-dimethoxy-phenethylamino)-2-hydroxypropoxy]thieno[3,2-c]pyridine-2-carbonitrile 

Relevant academic research and scientific papers

propanolamines. 1. Novel β-Blockers with Ultrashort Duration of Action

Novel propanolamines were synthesized and investigated as potential ultrashort-acting β-adrenergic receptor blockers.Many of these analogues exhibited good potency and short duration.The N-ureidoalkyl analogue 85 (ACC-9089) has a potency equal to propranolol and a duration of action of about 21 min in the dog.It has been selected as a candidate for further clinical study.Structure-activity relationships and structure-duration relationships for these new β-blockers are also discussed.

β1-Selective adrenoceptor antagonists: Examples of the 2-[4-[3-(substituted-amino)-2-hydroxypropoxy]phenyl]imidazole class

A series of 2-[4-[3-(substituted-amino)-2-hydroxypropoxy]phenyl]imidazoles is described. The compounds were investigated in vitro for β-adrenoceptor antagonism, and several examples were found to be selective for the β1-adrenoceptor. The structure-activity relationship exhibited by this series of compounds is discussed. (S)-2-[p-[3-[[2-(3,4-dimethoxyphenyl)ethyl]amino]-2-hydroxypropoxy]phenyl] -4-(2-thienyl)imidazole [(S)-13] was over 100 times more selective than atenolol for the β1-adrenergic receptor and has been selected for in-depth studies.

N-Aralkyl containing cyanopyridines

N-Aralkylamino-OR-propoxycyanopyridines having pharmacological activity are disclosed.