66787-70-0

Usage

Uses

Used in Organic Synthesis:
Ethyl 1-Methylimidazole-5-carboxylate is used as a reagent in organic synthesis for the preparation of various pharmaceutical and agrochemical products. Its unique chemical structure allows it to be a key component in the synthesis of a wide range of compounds.
Used in Manufacturing of Fine Chemicals and Specialty Materials:
Ethyl 1-Methylimidazole-5-carboxylate is also employed in the manufacturing of fine chemicals and specialty materials, where its properties contribute to the development of high-quality and specialized products.
Used in Medicinal Chemistry and Drug Development:
Due to its unique chemical structure and properties, Ethyl 1-Methylimidazole-5-carboxylate may have potential applications in the fields of medicinal chemistry and drug development, where it could be utilized in the creation of new therapeutic agents.
Used in Chemical Industry:
Overall, Ethyl 1-Methylimidazole-5-carboxylate plays a crucial role in the synthesis and production of various valuable products in the chemical industry, contributing to the advancement of numerous applications across different sectors.

InChI:InChI=1/C7H10N2O2/c1-3-11-7(10)6-4-8-5-9(6)2/h4-5H,3H2,1-2H3

Upstream product

• 23785-21-9 ethyl 1H-imidazole-4-carboxylate 
• 74-88-4 methyl iodide 
• 23785-21-9 1H-imidazole-5-carboxylic acid ethyl ester 

Downstream Products

• 23585-00-4 1-methyl-1H-imidazole-5-carboxylic acid hydrazide 
• 41806-40-0 1-methyl-1H-imidazole-5-carboxylic acid 
• 41064-98-6 3-methyl-3H-imidazole-4-carboxylic acid N'-benzenesulfonyl-hydrazide 
• 89180-90-5 5-(chloromethyl)-1-methyl-1H-imidazole 
• 39021-62-0 1-methylimidazole-5-carbaldehyde 

Relevant academic research and scientific papers

Derisking the Cu-Mediated 18F-Fluorination of Heterocyclic Positron Emission Tomography Radioligands

Molecules labeled with fluorine-18 (18F) are used in positron emission tomography to visualize, characterize and measure biological processes in the body. Despite recent advances in the incorporation of 18F onto arenes, the development of general and efficient approaches to label radioligands necessary for drug discovery programs remains a significant task. This full account describes a derisking approach toward the radiosynthesis of heterocyclic positron emission tomography (PET) radioligands using the copper-mediated 18F-fluorination of aryl boron reagents with 18F-fluoride as a model reaction. This approach is based on a study examining how the presence of heterocycles commonly used in drug development affects the efficiency of 18F-fluorination for a representative aryl boron reagent, and on the labeling of more than 50 (hetero)aryl boronic esters. This set of data allows for the application of this derisking strategy to the successful radiosynthesis of seven structurally complex pharmaceutically relevant heterocycle-containing molecules.

A new generation of aprotic yet Bronsted acidic imidazolium salts: Low toxicity, high recyclability and greatly improved activity

Catalysts which have low antimicrobial toxicity and are aprotic, yet which can act as Bronsted acidic catalysts in the presence of protic additives have been developed. The catalysts are recyclable, considerably more active (i.e. can be used at 10-50 times lower loadings) and of broader scope than their antecedent generation.

ARYL SUBSTITUTED IMIDAZO [4,5-C] PYRIDINE COMPOUNDS AS C3A RECEPTOR ANTAGONISTS

Aryl substituted imidazo[4,5-c] pyridine compounds of formula (I) or pharmaceutically acceptable salt thereof are provided. These compounds are useful in pharmaceutical compositions as C3a antagonists for treating a variety of medical conditions associated with the Complement cascade.

Synthesis and structure-activity relationships of new (5R,8R,10R)-ergoline derivatives with antihypertensive or dopaminergic activity

A series of new (5R,8R,10R)-ergoline derivatives was synthesized, and their antihypertensive and dopaminergic activities were tested in conscious spontaneously hypertensive rats and in rats with unilateral 6- hydroxydopamine-induced lesions of the substantia nigra. (5R,8R,10R)-6- Alkyl-8-ergolinemethanols, prepared from the corresponding ergolinecarboxylates, were converted to the tosylates, which were treated with various five-membered heterocycles containing nitrogen atoms to afford the new ergolines. (5R,8R,10R)-8-(1,2,4-Triazol-1-ylmethyl)-6-methylergoline (4s, maleate: BAM-1110) exhibited potent dopaminergic activity, about 18- fold greater than that of bromocriptine mesylate. (5R,8R,10R)-8-(1,2,4- Triazol-1-ylmethyl)-6-propylergoline (8b, fumarate: BAM-1602) showed extremely potent dopaminergic activity, being about 220 and 1.15 times more active than bromocriptine mesylate and pergolide mesylate, respectively. Several compounds exhibited potent antihypertensive activity. Structure- activity relationships for antihypertensive and dopaminergic activities are discussed.