66787-70-0

Basic information

• Product Name: Ethyl 1-Methylimidazole-5-carboxylate
• Synonyms: Ethyl 1-Methylimidazole-5-carboxylate;ethyl 1-Methyl-1H-iMidazole-5-carboxylate;1-Methyl-1H-imidazole-5-carboxylic acid ethyl ester;3-Methyl-3H-imidazole-4-carboxylic acid ethyl ester;Ethyl 1-methyl-5-imidazolecarboxylate;Ro 31-0886
• CAS NO: 66787-70-0
• Molecular Formula: C₇H₁₀N₂O₂
• Molecular Weight: 154
• Mol File: 66787-70-0.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 294.9°C at 760 mmHg
• Flash Point: 132.2°C
• Appearance: /
• Density: 1.14g/cm³
• Vapor Pressure: 0.00157mmHg at 25°C
• Refractive Index: 1.525
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: Ethyl 1-Methylimidazole-5-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: Ethyl 1-Methylimidazole-5-carboxylate(66787-70-0)
• EPA Substance Registry System: Ethyl 1-Methylimidazole-5-carboxylate(66787-70-0)

Safety Data

• Hazardous Substances Data: 66787-70-0(Hazardous Substances Data)

Usage

General Description

Ethyl 1-Methylimidazole-5-carboxylate is a chemical compound that belongs to the family of imidazole derivatives. It is an ester formed from ethyl alcohol and 1-methylimidazole-5-carboxylic acid. Ethyl 1-Methylimidazole-5-carboxylate is commonly used in organic synthesis as a reagent for the preparation of various pharmaceutical and agrochemical products. It is also employed in the manufacturing of fine chemicals and specialty materials. Ethyl 1-Methylimidazole-5-carboxylate may also have potential applications in the fields of medicinal chemistry and drug development due to its unique chemical structure and properties. Overall, this compound plays a crucial role in the synthesis and production of various valuable products in the chemical industry.

InChI:InChI=1/C7H10N2O2/c1-3-11-7(10)6-4-8-5-9(6)2/h4-5H,3H2,1-2H3

Upstream product

• 23785-21-9 1H-imidazole-5-carboxylic acid ethyl ester 
• 74-88-4 methyl iodide 
• 23785-21-9 ethyl 1H-imidazole-4-carboxylate 

Downstream Products

• 41806-40-0 1-methyl-1H-imidazole-5-carboxylic acid 
• 41064-98-6 3-methyl-3H-imidazole-4-carboxylic acid N'-benzenesulfonyl-hydrazide 
• 89180-90-5 5-(chloromethyl)-1-methyl-1H-imidazole 
• 39021-62-0 1-methylimidazole-5-carbaldehyde 
• 23585-00-4 1-methyl-1H-imidazole-5-carboxylic acid hydrazide 

Relevant articles and documents

Derisking the Cu-Mediated 18F-Fluorination of Heterocyclic Positron Emission Tomography Radioligands

Molecules labeled with fluorine-18 (18F) are used in positron emission tomography to visualize, characterize and measure biological processes in the body. Despite recent advances in the incorporation of 18F onto arenes, the development of general and efficient approaches to label radioligands necessary for drug discovery programs remains a significant task. This full account describes a derisking approach toward the radiosynthesis of heterocyclic positron emission tomography (PET) radioligands using the copper-mediated 18F-fluorination of aryl boron reagents with 18F-fluoride as a model reaction. This approach is based on a study examining how the presence of heterocycles commonly used in drug development affects the efficiency of 18F-fluorination for a representative aryl boron reagent, and on the labeling of more than 50 (hetero)aryl boronic esters. This set of data allows for the application of this derisking strategy to the successful radiosynthesis of seven structurally complex pharmaceutically relevant heterocycle-containing molecules.

ARYL SUBSTITUTED IMIDAZO [4,5-C] PYRIDINE COMPOUNDS AS C3A RECEPTOR ANTAGONISTS

Aryl substituted imidazo[4,5-c] pyridine compounds of formula (I) or pharmaceutically acceptable salt thereof are provided. These compounds are useful in pharmaceutical compositions as C3a antagonists for treating a variety of medical conditions associated with the Complement cascade.