667898-99-9Relevant articles and documents
4-Amino cyclohexylglycine analogues as potent dipeptidyl peptidase IV inhibitors
Parmee, Emma R.,He, Jiafang,Mastracchio, Anthony,Edmondson, Scott D.,Colwell, Larry,Eiermann, George,Feeney, William P.,Habulihaz, Bahanu,He, Huaibing,Kilburn, Ruth,Leiting, Barbara,Lyons, Kathryn,Marsilio, Frank,Patel, Reshma A.,Petrov, Aleksandr,Di Salvo, Jerry,Wu, Joseph K.,Thornberry, Nancy A.,Weber, Ann E.
, p. 43 - 46 (2007/10/03)
Substituted 4-amino cyclohexylglycine analogues were evaluated for DP-IV inhibitory properties. Bis-sulfonamide 15e was an extremely potent 2.6 nM inhibitor of the enzyme with excellent selectivity over all counterscreens. 2,4-Difluorobenzenesulfonamide 1