14446-47-0

Basic information

• Product Name: Thiazolidine, hydrochloride (1:1)
• Synonyms: Thiazolidine, hydrochloride (1:1);Thiazolidine hydrochloride;Thiazolidine hcl;THIAZOLIDINE, HCL (1:1)
• CAS NO: 14446-47-0
• Molecular Formula: C₃H₇NS*ClH
• Molecular Weight: 125.62032
• Mol File: 14446-47-0.mol

Chemical Properties

• Melting Point: 180 °C(Solv: water (7732-18-5))
• Appearance: /
• CAS DataBase Reference: Thiazolidine, hydrochloride (1:1)(CAS DataBase Reference)
• NIST Chemistry Reference: Thiazolidine, hydrochloride (1:1)(14446-47-0)
• EPA Substance Registry System: Thiazolidine, hydrochloride (1:1)(14446-47-0)

Safety Data

• Hazardous Substances Data: 14446-47-0(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Synthesis:
Thiazolidine, hydrochloride (1:1) is used as a key intermediate in the synthesis of various pharmaceutical compounds. Its unique structure and reactivity make it a valuable building block for the development of new drugs with diverse therapeutic applications.
Used in Agrochemical Production:
In the agrochemical industry, Thiazolidine, hydrochloride (1:1) serves as a crucial component in the production of various agrochemicals. Its incorporation aids in enhancing the effectiveness of these products, contributing to improved crop protection and yield.
Used in Medicinal Chemistry Research:
Thiazolidine, hydrochloride (1:1) is utilized as a subject of interest in medicinal chemistry research. Its potential anti-inflammatory and anti-cancer activities make it a promising candidate for the development of novel therapeutic agents targeting inflammatory diseases and cancer.
Used in Chemical Reactions:
Due to its unique properties, Thiazolidine, hydrochloride (1:1) is employed in a variety of chemical reactions. Its versatility allows it to participate in numerous processes, facilitating the synthesis of a wide range of chemical products.

Upstream product

• 50-00-0 formaldehyd 
• 156-57-0 2-mercaptoethylamine hydrochloride 

Downstream Products

• 874509-58-7 3-(4-nitro-benzenesulfonyl)-thiazolidine 
• 667898-99-9 [1-(4-azido-cyclohexyl)-2-oxo-2-thiazolidin-3-yl-ethyl]-carbamic acid tert-butyl ester 
• 133913-49-2 1-phenyl-3-thiazolidin-3-yl-propan-1-one 
• 1024025-54-4 5-phenethyl-2,3,4,7-tetrahydro[1,4]thiazepine-6-carbonitrile 
• 1024025-70-4 5-phenyl-2,3,4,7-tetrahydro[1,4]thiazepine-6-carbonitrile 
• 33744-33-1 β-methylaminoethanethiol hydrochloride 
• 401566-80-1 tert-butyl (2S,4S)-4-[4-(3-methyl-1-phenyl-1H-pyrazol-5-yl)piperazin-1-yl]-2-(1,3-thiazolidin-3-ylcarbonyl)pyrrolidine-1-carboxylate 
• 401564-36-1 (2S)-4-oxo-2-(3-thiazolidinylcarbonyl)-1-pyrrolidinecarboxylic acid tert-butyl ester 

Relevant articles and documents

Reversible inactivation of bovine plasma amine oxidase by cysteamine and related analogs

Cysteamine (1) was reported many years ago to reversibly inhibit lentil seedling amine oxidase, through the formation of a complex with thioacetaldehyde, the turnover product of 1. Herein, cysteamine (1) and its analogs 2-(methylamino)ethanethiol (3) and 3-aminopropanethiol (6) were found to be reversible inhibitors of bovine plasma amine oxidase (BPAO), but 2-(methylthio)ethylamine (7) was determined to be a weak irreversible inhibitor of BPAO. Based on our results, indicating the necessity of a sulfhydryl-amine for reversible inactivation of BPAO, the failure of inhibited BPAO to recover activity after gel filtration, the first-order kinetics of activity recovery upon dialysis, and 2,4,6-trihydroxyphenylalanine quinine (TPQ) cofactor transformation which indicated from the results of phenylhydrazine titration and substrate protection, we propose a mechanism for the reversible inactivation of BPAO by 1 involving the formation of a cofactor adduct, thiazolidine, between BPAO and 1.

PROCESS FOR THE PREPARATION OF TENELIGLIPTIN AND ITS NOVEL INTERMEDIATES

The present invention relates to a novel process for the preparation of Teneligliptin or its pharmaceutically acceptable salts and its hydrates thereof. The invention also relates to novel intermediates used in the synthesis of Teneligliptin and their preparation.

Synthesis of 2,3,4,7-tetrahydro[1,4]thiazepines from thiazolidines and β-enaminonitriles

A wide library of 2,3,4,7-tetrahydro[1,4]thiazepines have been prepared by simple heating of thiazolidine and β-enaminonitrile derivatives in acetonitrile. The procedure, whose yields depend on the nature and position of the substituents, gave good results if the substituents were not very bulky but it is less effective when starting from 2-substituted thiazolidines.