66790-60-1

Basic information

• Product Name: 3-(2-bromo-3-methylphenyl)propionic acid
• Synonyms: 3-(2-bromo-3-methylphenyl)propionic acid
• CAS NO: 66790-60-1
• Molecular Weight: 243.1
• Mol File: 66790-60-1.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 3-(2-bromo-3-methylphenyl)propionic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(2-bromo-3-methylphenyl)propionic acid(66790-60-1)
• EPA Substance Registry System: 3-(2-bromo-3-methylphenyl)propionic acid(66790-60-1)

Safety Data

• Hazardous Substances Data: 66790-60-1(Hazardous Substances Data)

Upstream product

• 53663-39-1 3-methyl-2-bromobenzoic acid 
• 2033-24-1 cycl-isopropylidene malonate 
• 109179-31-9 2-bromo-3-methyl-benzaldehyde 

Relevant articles and documents

Highly Diastereoselective Synthesis of Medium-Sized Carbocycle-Fused Piperidines via Sequential Hydride Shift Triggered Double C(sp3)-H Bond Functionalization

Herein we report a diastereoselective synthesis of medium-sized carbocycle-fused piperidines via [1,n (n = 6, 7)]-[1,5]-sequential hydride shift triggered double C(sp3)-H bond functionalization. When cinnamylidene malonates having N,N-dibenzyl propylamine moiety were treated with 5 mol % of Yb(OTf)3, a [1,6]-[1,5]-sequential hydride shift/cyclization process proceeded to afford seven-membered carbocycle-fused piperidines with excellent diastereoselectivities. This sequential system was applicable to the synthesis of eight-membered carbocycle-fused piperidines by an unprecedented [1,7]-[1,5]-sequential hydride shift/cyclization process.