667919-12-2

Basic information

• Product Name: 1H-Benzimidazole, 4-methyl-1-phenyl-
• CAS NO: 667919-12-2
• Molecular Formula: C14H12N2
• Molecular Weight: 208.263
• Mol File: 667919-12-2.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 1H-Benzimidazole, 4-methyl-1-phenyl-(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-Benzimidazole, 4-methyl-1-phenyl-(667919-12-2)
• EPA Substance Registry System: 1H-Benzimidazole, 4-methyl-1-phenyl-(667919-12-2)

Safety Data

• Hazardous Substances Data: 667919-12-2(Hazardous Substances Data)

Upstream product

• 122-51-0 orthoformic acid triethyl ester 
• 105973-93-1 3-methyl-N₁-phenylbenzene-1,2-diamine 
• 601-87-6 3-methyl-2-nitroaniline 
• 108-86-1 bromobenzene 
• 3473-63-0 formamidine acetic acid 
• 591-50-4 iodobenzene 
• 4887-83-6 7-methyl-1H-benzo[d]imidazole 
• 220495-97-6 3-methyl-2-nitrodiphenylamine 

Downstream Products

• 667919-14-4 1-phenyl-1H-benzoimidazole-4-carboxylic acid 

Relevant articles and documents

Ni-Catalyzed Dual C-H Annulation of Benzimidazoles with Alkynes for Synthesis of π-Extended Heteroarenes

Transition metal catalyzed dual C-H activation and annulation with alkynes was an attractive protocol to construct polycyclic π-extended structures. However, most of them were dominated by noble metal catalysts. Disclosed herein was the study of base-metal Ni-catalysis for dual C-H annulation of N-aromatic imidazole, which produced a range of desired polycyclic aza-quinolines in 48-95% yields. The use of bifunctional phosphine oxide ligand proved to be critical for success.

Structure-activity relationships for 1-phenylbenzimidazoles as selective ATP site inhibitors of the platelet-derived growth factor receptor

1-Phenylbenzimidazoles are shown to be a new class of ATP-site inhibitors of the platelet-derived growth factor receptor (PDGFR). Structure- activity relationships (SARs) are narrow, with closely related heterocycles being inactive. A systematic study of