667920-79-8

Upstream product

• 1260243-53-5 ethyl 7,7-dimethyl-5-phenyl-4,7-dihydropyrazolo[1,5-a]pyrimidine-3-carboxylate 
• 1260243-04-6 ethyl 5-amino-1H-pyrazole-4-carboxylate 
• 5650-07-7 3-methyl-1-phenyl-but-2-en-1-one 

Downstream Products

• 667921-18-8 7,7-dimethyl-5-phenyl-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidine-3-carboxylic acid 
• 1268168-12-2 N-{1-isopropyl-2-methyl-1-[4-(trifluoromethyl)phenyl]propyl}-7,7-dimethyl-5-phenyl-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidine-3-carboxamide hydrochloride 
• 667925-58-8 N-{1-butyl-1-[4-(trifluoromethyl)phenyl]pentyl}-7,7-dimethyl-5-phenyl-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidine-3-carboxamide 
• 667925-53-3 7,7-dimethyl-5-phenyl-N-{1-propyl-1-[4-(trifluoromethyl)phenyl]-butyl}-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidine-3-carboxamide 
• 667921-51-9 N-{1-ethyl-1-[4-(trifluoromethyl)phenyl]propyl}-7,7-dimethyl-5-phenyl-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidine-3-carboxamide 
• 667925-74-8 7,7-dimethyl-N-{1-methyl-1-[4-(trifluoromethyl)phenyl]ethyl}-5-phenyl-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidine-3-carboxamide 
• 667930-97-4 (5S)-N-{1-ethyl-1-[4-(trifluoromethyl)phenyl]propyl}-7,7-dimethyl-5-phenyl-4,5,6-,7-tetrahydropyrazolo[1,5-a]pyrimidine-3-carboxamide 
• 668486-08-6 (5S)-(+)-N-[1-ethyl-1-(4-methylphenyl)propyl]-7,7-dimethyl-5-phenyl-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidine-3-carboxamide hydrochloride 
• 667930-84-9 (5S)-(-)-7,7-dimethyl-5-phenyl-4,5,6,7-tetrahydropyrazolo[ 1,5-a]-pyrimidine-3-carboxylic acid 
• 667930-85-0 (5R)-(+)-7,7-dimethyl-5-phenyl-4,5,6,7-tetrahydropyrazolo[ 1,5-a]-pyrimidine-3-carboxylic acid 
• 1268251-96-2 ethyl (5S)-7,7-dimethyl-5-phenyl-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidine-3-carboxylate 
• 1268251-95-1 ethyl (5R)-7,7-dimethyl-5-phenyl-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidine-3-carboxylate 
• 667928-77-0 ethyl (4-(1-(((7,7-dimethyl-5-phenyl-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidin-3-yl)carbonyl)amino)-1-ethylpropyl)phenoxy)acetate 
• 667928-75-8 4-(1-{[ (7,7-dimethyl-5-phenyl-4,5,6,7-tetrahydropyrazolo[1,5-a]-pyrimidine-3-yl)carbonyl]-amino}-1-ethylpropyl)phenyl acetate 

Relevant academic research and scientific papers

Substituted pyrazolo[1,5-A] pyrimidines as calcium receptor modulating agents

There is provided a calcium receptor modulator comprising a compound of the formula (I): wherein ring A is an optionally substituted 5- to 7-membered ring; ring B is an optionally substituted 5- to 7-membered heterocyclic ring; X1 is CR1/

Discovery of novel and potent orally active calcium-sensing receptor antagonists that stimulate pulselike parathyroid hormone secretion: Synthesis and structure-activity relationships of tetrahydropyrazolopyrimidine derivatives

As part of our research for novel calcium-sensing receptor (CaSR) antagonists that can function as oral bone anabolic agents, we recently reported the discovery of a tetrahydropyrazolopyrimidine derivative featuring adamantyl group 1b with potent CaSR ant

Synthesis and structure-activity relationship of tetrahydropyrazolopyrimidine derivatives - A novel structural class of potent calcium-sensing receptor antagonists

A series of novel tetrahydropyrazolopyrimidine derivatives containing an adamantyl group were synthesized and evaluated as potential calcium-sensing receptor (CaSR) antagonists. After chemical modification of 9a, which was identified as a hit compound in