667936-68-7Relevant academic research and scientific papers
Structure-activity relationships of trimethoxybenzyl piperazine N-type calcium channel inhibitors
Pajouhesh, Hassan,Feng, Zhong-Ping,Zhang, Lingyun,Pajouhesh, Hossein,Jiang, Xinpo,Hendricson, Adam,Dong, Haiheng,Tringham, Elizabeth,Ding, Yanbing,Vanderah, Todd W.,Porreca, Frank,Belardetti, Francesco,Zamponi, Gerald W.,Mitscher, Lester A.,Snutch, Terrance P.
scheme or table, p. 4153 - 4158 (2012/07/14)
We previously reported the small organic N-type calcium channel blocker NP078585 that while efficacious in animal models for pain, exhibited modest L-type calcium channel selectivity and substantial off-target inhibition against the hERG potassium channel
Scaffold-based design and synthesis of potent N-type calcium channel blockers
Zamponi, Gerald W.,Feng, Zhong-Ping,Zhang, Lingyun,Pajouhesh, Hossein,Ding, Yanbing,Belardetti, Francesco,Pajouhesh, Hassan,Dolphin, David,Mitscher, Lester A.,Snutch, Terrance P.
scheme or table, p. 6467 - 6472 (2010/04/30)
The therapeutic agents flunarizine and lomerizine exhibit inhibitory activities against a variety of ion channels and neurotransmitter receptors. We have optimized their scaffolds to obtain more selective N-type calcium channel blockers. During this optim
Calcium channel inhibitors comprising benzhydril spaced from piperazine
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, (2008/06/13)
Certain piperazine substituted compounds are described which are useful in altering calcium channel activity.
Calcium channel inhibitors comprising benzhydril spaced from piperazine
-
, (2008/06/13)
Certain piperazine substituted compounds are described which are useful in altering calcium channel activity.
Calcium channel inhibitors comprising benzhydril spaced from piperazine
-
, (2008/06/13)
Certain piperazine substituted compounds are described which are useful in altering calcium channel activity.
