66794-12-5

Usage

Physical state

Colorless to pale yellow liquid

Odor

Strong aromatic

Uses

a. Fragrance ingredient in perfumes
b. Flavoring agent in food products
c. Production of chemicals and pharmaceuticals

Toxicity

Low toxicity

Environmental impact

Not known to cause significant harm under normal conditions of use

Safety precautions

Handle with care and follow proper safety measures

Upstream product

• 624-92-0 Dimethyldisulphide 
• 2725-82-8 1-bromo-3-ethylbenzene 
• 4886-77-5 3-methylthioanisole 
• 74-88-4 methyl iodide 
• 62154-77-2 3-ethyl-thiophenol 
• 77-78-1 dimethyl sulfate 

Relevant academic research and scientific papers

Lewis Acid–Base Interaction-Controlled ortho-Selective C?H Borylation of Aryl Sulfides

An iridium/bipyridine-catalyzed ortho-selective C?H borylation of aryl sulfides was developed. High ortho-selectivity was achieved by a Lewis acid–base interaction between a boryl group of the ligand and a sulfur atom of the substrate. This is the first example of a catalytic and regioselective C?H transformation controlled by a Lewis acid–base interaction between a ligand and a substrate. The C?H borylation reaction could be conducted on a gram scale, and with a bioactive molecule as a substrate, demonstrating its applicability to late-stage regioselective C?H borylation. A bioactive molecule was synthesized from an ortho-borylated product by converting the boryl and methylthio groups of the product.

TRIAZOLOPYRIDINE COMPOUNDS AND USES THEREOF

A compound of Formula (IA), or a pharmaceutically acceptable salt thereof, is provided that has been shown to be useful for treating a PRC2-mediated disease or disorder: wherein A, R6, R7 and R8 are as defined herein.

Metallation reactions. XXI. Metallation of alkyl (alkylthio) benzenes by superbases versus organolithium compounds

The metallation regiochemistry of alkyl(alkylthio)benzenes with butyllithium or with the superbasic mixture of butyllithium with potassium tert-butoxide is described. The reaction pattern depends on the substrate and the reagent. Butyllithium monometallates the thiomethylic carbon of methyl (methylthio) benzenes and bimetallates the thiomethylic and the annular carbon ortho to the thioethereal group. With superbases the metallation occurs at the thiomethylic and methylic carbon. Metallation with butyllithium of the higher homologs substitutes exclusively the hydrogen ortho to the thioalkylic group, while the superbases attack also the carbon atom alpha to the thioalkyl substituent.