668261-28-7Relevant academic research and scientific papers
Preparation of novel antibacterial agents. Replacement of the central aromatic ring with heterocycles
Li, Jianke,Wakefield, Brian D.,Ruble, J. Craig,Stiff, Cory M.,Romero, Donna L.,Marotti, Keith R.,Sweeney, Michael T.,Zurenko, Gary E.,Rohrer, Douglas C.,Thorarensen, Atli
, p. 2347 - 2350 (2008/12/21)
Discovery of novel antibacterial agents is a significant challenge. We have recently reported on our discovery of novel antibacterial agents in which we have rapidly optimized potency utilizing a parallel chemistry approach. These advanced leads suffer from high affinity for human serum albumin (HSA). In an effort to decrease the affinity for HSA we have prepared a series of heterocyclic analogs, which retained antibacterial activity and demonstrated reduced affinity for HSA.
ANTIBACTERIAL BENZOIC ACID DERIVATIVES
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Page 368-369, (2010/02/06)
The invention provides antimicrobial agents and methods of using the agents for sterilization, sanitation, antisepsis, disinfection, and treatment of infections in mammals.
ANTIBACTERIAL AGENTS
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Page 25-26, (2010/02/06)
The present invention relates to antibacterial agents that are useful for sterilization, sanitation, antisepsis, and disinfection.
