668455-70-7

Usage

Uses

Used in Perfumery and Fragrance Industry:
Benzoic acid, 4-methoxy-2-(2-propenyloxy)-, is used as a fragrance ingredient for its aromatic properties, contributing to the creation of various perfumes and other scented products.
Used in Food and Beverage Industry:
In the food and beverage sector, Benzoic acid, 4-methoxy-2-(2-propenyloxy)- serves as a flavoring agent, enhancing the taste and aroma of a range of products.
Used as a Preservative:
Benzoic acid, 4-methoxy-2-(2-propenyloxy)-, is utilized as a preservative in different products to extend their shelf life and maintain their quality over time.
Used in Pharmaceutical Industry:
Benzoic acid, 4-methoxy-2-(2-propenyloxy)has potential applications in the pharmaceutical field, where it may be used in the development of medications or as an intermediate for the synthesis of other pharmaceutical compounds.
Used in Organic Synthesis:
Benzoic acid, 4-methoxy-2-(2-propenyloxy)-, also functions as an intermediate in organic synthesis, playing a crucial role in the production of various organic compounds.
It is important to handle Benzoic acid, 4-methoxy-2-(2-propenyloxy)-, with care due to its potential to cause irritation and harmful effects if not used properly.

Upstream product

• 31456-95-8 Methyl 4-methoxy-2-(prop-2-enyloxy)benzoate 
• 2237-36-7 4-methoxysalicylic acid 
• 5446-02-6 4-methoxymethylsalicylate 
• 106-95-6 allyl bromide 

Downstream Products

• 13677-76-4 2-allyl-5-methoxyphenol 
• 87359-53-3 2-allyloxy-4-methoxy benzoyl chloride 
• 1374817-67-0 C₃₅H₃₉N₃O₈ 
• 1374817-56-7 C₃₅H₃₉N₃O₈ 
• 1374817-63-6 C₃₇H₄₃N₃O₈ 
• 132608-52-7 2-(allyloxy)-1-bromo-4-methoxybenzene 

Relevant academic research and scientific papers

Transition-Metal-Free Decarboxylative Iodination: New Routes for Decarboxylative Oxidative Cross-Couplings

Constructing products of high synthetic value from inexpensive and abundant starting materials is of great importance. Aryl iodides are essential building blocks for the synthesis of functional molecules, and efficient methods for their synthesis from chemical feedstocks are highly sought after. Here we report a low-cost decarboxylative iodination that occurs simply from readily available benzoic acids and I2. The reaction is scalable and the scope and robustness of the reaction is thoroughly examined. Mechanistic studies suggest that this reaction does not proceed via a radical mechanism, which is in contrast to classical Hunsdiecker-type decarboxylative halogenations. In addition, DFT studies allow comparisons to be made between our procedure and current transition-metal-catalyzed decarboxylations. The utility of this procedure is demonstrated in its application to oxidative cross-couplings of aromatics via decarboxylative/C-H or double decarboxylative activations that use I2 as the terminal oxidant. This strategy allows the preparation of biaryls previously inaccessible via decarboxylative methods and holds other advantages over existing decarboxylative oxidative couplings, as stoichiometric transition metals are avoided.

Oxidative cyclization of alkenoic acids promoted by AgOAc

Alkenoic acids derived from salicylic acid and analogues undergo an unexpected oxidative cyclization process triggered by AgOAc leading to 4H-benzo[d][1,3]dioxin-4-ones. The process is affected by the substitution on the aryl and the allyl units.

General route for the preparation of diverse 17-membered macrocycles based on RCM and examination of the E/Z selectivity

(Chemical Equation Presented) A convergent, general synthetic route to 17-membered macrocycles was developed to support biological evaluation and structure-activity relationship (SAR) studies during phenotypic screening for immunology targets. A series of amide coupling reactions led to a ring-closing metathesis (RCM) precursor that was cyclized using Grubbs' catalysts. It was found that the reaction formed the macrocyclic products in a 3:1 ratio of E/Z isomers. Moreover, it was shown that a number of similarly substituted RCM precursors undergo cyclization to produce the geometric E/Z isomers in roughly the same 3:1 ratio. The remarkable independence of the E/Z outcome from the substitution pattern of the RCM precursor makes this synthetic approach generally applicable. Separation of the E/Z isomers was achieved by preparative high-performance liquid chromatography and allowed biological profiling of the geometric isomers. Reactive groups in the macrocycle were utilized for late-stage modifications in the fashion of diversity-orientated synthesis (DOS), yielding analogs for SAR studies. Copyright Rigel Pharmaceuticals, Inc.

ALLYLQXY AND ALKYLOXY BENZOIC ACID DELIVERY AGENTS

The present invention relates to pharmaceutical compounds for delivering active agents, such as biologically or chemically active agents, to a target. The invention also relates to pharmaceutical compositions comprising at least one delivery agent compound of the present invention and at least one active agent, and unit dosage forms comprising such compositions. Methods for the preparation and administration of the pharmaceutical compositions are also disclosed.

INDOLES HAVING ANTI-DIABETIC ACTIVITY

Indoles of Formula (I) having -X-aryl-(CH2)x#191-oxazolidinedione and -X-heteroaryl-(CH2)X-oxazolidinedione substituents on the N atom of the indole ring, where x is 0 or 1, and -X-is a bond or -CH2-, and their thiazolidinedione analogs, are PPAR gamma agonists or partial agonists and are useful in the treatment and control of type II diabetes, including hyperglycemia, dyslipidemia, hyperlipidemia, hypercholesterolemia, hypertriglyceridemia, and obesity that are often associated with type 2 diabetes.

INDOLES HAVING ANTI-DIABETIC ACTIVITY

Indoles having aryloxyalkanoic acid substituents or arylalkanoic acid substituents are agonists or partial agonists of PPAR gamma and are useful in the treatment and control of hyperglycemia that is symptomatic of type II diabetes, as well as dyslipidemia, hyperlipidemia, hypercholesterolemia, hypertriglyceridemia, and obesity that are often associated with type 2 diabetes.