668455-74-1Relevant academic research and scientific papers
Selective PPARγ modulators with improved pharmacological profiles
Liu, Kun,Black, Regina M.,Acton III, John J.,Mosley, Ralph,Debenham, Sheryl,Abola, Ramon,Yang, Meng,Tschirret-Guth, Richard,Colwell, Lawrence,Liu, Cherrie,Wu, Margaret,Wang, Chuanlin F.,MacNaul, Karen L.,McCann, Margaret E.,Moller, David E.,Berger, Joel P.,Meinke, Peter T.,Jones, A. Brian,Wood, Harold B.
, p. 2437 - 2440 (2005)
A series of metabolically robust N-benzyl-indole selective PPARγ modulators with either a 3-benzoyl or 3-benzisoxazoyl moiety have been identified. In vitro, these compounds are partial agonists and exhibit reduced adipogenesis in human adipocytes. In vivo, these SPPARγMs result in potent glucose lowering in db/db mice and attenuate increases in heart weight and brown adipose tissue that is typically observed in rats upon treatment with PPARγ full agonists.
