668455-75-2Relevant academic research and scientific papers
INDOLES HAVING ANTI-DIABETIC ACTIVITY
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Page/Page column 36, (2008/06/13)
Indoles of Formula (I) having -X-aryl-(CH2)x#191-oxazolidinedione and -X-heteroaryl-(CH2)X-oxazolidinedione substituents on the N atom of the indole ring, where x is 0 or 1, and -X-is a bond or -CH2-, and their thiazolidinedione analogs, are PPAR gamma agonists or partial agonists and are useful in the treatment and control of type II diabetes, including hyperglycemia, dyslipidemia, hyperlipidemia, hypercholesterolemia, hypertriglyceridemia, and obesity that are often associated with type 2 diabetes.
Selective PPARγ modulators with improved pharmacological profiles
Liu, Kun,Black, Regina M.,Acton III, John J.,Mosley, Ralph,Debenham, Sheryl,Abola, Ramon,Yang, Meng,Tschirret-Guth, Richard,Colwell, Lawrence,Liu, Cherrie,Wu, Margaret,Wang, Chuanlin F.,MacNaul, Karen L.,McCann, Margaret E.,Moller, David E.,Berger, Joel P.,Meinke, Peter T.,Jones, A. Brian,Wood, Harold B.
, p. 2437 - 2440 (2007/10/03)
A series of metabolically robust N-benzyl-indole selective PPARγ modulators with either a 3-benzoyl or 3-benzisoxazoyl moiety have been identified. In vitro, these compounds are partial agonists and exhibit reduced adipogenesis in human adipocytes. In vivo, these SPPARγMs result in potent glucose lowering in db/db mice and attenuate increases in heart weight and brown adipose tissue that is typically observed in rats upon treatment with PPARγ full agonists.
INDOLES HAVING ANTI-DIABETIC ACTIVITY
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Page 73-74, (2010/02/06)
Indoles having aryloxyalkanoic acid substituents or arylalkanoic acid substituents are agonists or partial agonists of PPAR gamma and are useful in the treatment and control of hyperglycemia that is symptomatic of type II diabetes, as well as dyslipidemia, hyperlipidemia, hypercholesterolemia, hypertriglyceridemia, and obesity that are often associated with type 2 diabetes.
