668462-17-7Relevant academic research and scientific papers
The design and synthesis of novel inhibitors of NADH:ubiquinone oxidoreductase
Lindell, Stephen D.,Ort, Oswald,Luemmen, Peter,Klein, Robert
, p. 511 - 514 (2004)
Potent new inhibitors of NADH:ubiquinone oxidoreductase (complex I) have been designed, with the help of molecular modelling, by hybridisation of known complex I inhibitors with inhibitors of cytochrome c oxidoreductase. The most interesting compound was the chromone 7 which was a selective inhibitor of complex I (IC50 15 nM) and showed acaricidal activity against spider mites.
