668475-86-3

Upstream product

• 13360-57-1 dimethylamino sulfonyl chloride 
• 668475-78-3 5-cyclohexylmethyl-4-ethyl-1H-imidazole 
• 628319-02-8 4-cyclohexylmethyl-5-ethyl-1,3-dihydroimidazole-2-thione 

Downstream Products

• 668475-89-6 5-cyclohexylmethyl-4-ethyl-2-hydroxymethylimidazole-1-sulfonic acid dimethylamide 

Relevant academic research and scientific papers

Synthesis of 2-Hydroxymethyl-1H-imidazoles from 1,3-Dihydroimidazole-2- thiones

1,3-Dihydroimidazole-2-thiones 1a-d were desulfurized by hydrogen peroxide in either acid or neutral medium to afford 1H-imidazoles 3a-d. Reaction of 3b,d with dimethylsulfamoyl chloride furnished N,N-dimethylsulfamoylimidazoles 5 and 6a,b. Lithiation of 5 and 6a,b followed by formylation and reduction yielded the 2-hydroxymethyl derivatives 7 and 8a,b. 4-Alkyl-5-cyclohexylmethyl-1H- imidazol-2-yl)methanols 9a,b were obtained by hydrolysis of 7 and 8a,b.