668490-25-3

Upstream product

• 103-69-5 N-ethyl-N-phenylamine 
• 619-66-9 4-Carboxybenzaldehyde 
• 36282-40-3 (3-methoxyphenyl)magnesium bromide 
• 668490-23-1 N-ethyl-4-formyl-N-phenylbenzamide 

Downstream Products

• 738578-91-1 4-[(4-allyl-2,5-dimethyl-piperazin-1-yl)-(3-hydroxy-phenyl)-methyl]-N-ethyl-N-phenyl-benzamide 
• 668490-31-1 4-[(4-allyl-2,5-dimethyl-piperazin-1-yl)-(3-methoxy-phenyl)-methyl]-N-ethyl-N-phenyl-benzamide 
• 668490-33-3 4-[(4-allyl-2,5-dimethyl-piperazin-1-yl)-(3-methoxy-phenyl)-methyl]-N-ethyl-N-phenyl-benzamide 
• 769920-30-1 4-[(2,5-dimethyl-piperazin-1-yl)-(3-methoxy-phenyl)-methyl]-N-ethyl-N-phenyl-benzamide 
• 668490-29-7 4-[((2S,5S)-dimethyl-1-piperazinyl)-(3-methoxyphenyl)methyl]-N-ethyl-N-phenylbenzamide 
• 775578-48-8 {4-[(R)-((2S,5S)-2,5-Dimethyl-piperazin-1-yl)-(3-methoxy-phenyl)-methyl]-benzyl}-ethyl-phenyl-amine 
• 668490-39-9 {4-[(R)-((2S,5S)-4-Allyl-2,5-dimethyl-piperazin-1-yl)-(3-methoxy-phenyl)-methyl]-phenyl}-methanol 
• 668490-27-5 4-[chloro-(3-methoxyphenyl)methyl]-N-ethyl-N-phenylbenzamide 

Relevant academic research and scientific papers

Diaryldimethylpiperazine ligands with μ- and δ-opioid receptor affinity: Synthesis of (+)-4-[(αR)-α -(4-allyl-(2S,5S)-dimethylpiperazin-1-yl)-(3-hydroxyphenyl)methyl] -N-ethyl-N-phenylbenzamide and (-)-4-[(αR)-α -(2S,5S)-dimethylpiperazin-1-yl)-(3-hydroxy

We have explored the synthesis of compounds that have good affinity for both μ- and δ-opioid receptors from the (αR,2S,5S) class of diaryldimethylpiperazines. These non-selective compounds were related to opioids that have been found to interact selective