668490-39-9Relevant academic research and scientific papers
Diaryldimethylpiperazine ligands with μ- and δ-opioid receptor affinity: Synthesis of (+)-4-[(αR)-α -(4-allyl-(2S,5S)-dimethylpiperazin-1-yl)-(3-hydroxyphenyl)methyl] -N-ethyl-N-phenylbenzamide and (-)-4-[(αR)-α -(2S,5S)-dimethylpiperazin-1-yl)-(3-hydroxy
Kim, In Jong,Ullrich, Thomas,Janetka, James W.,Furness, M. Scott,Jacobson, Arthur E.,Rothman, Richard B.,Dersch, Christina M.,Flippen-Anderson, Judith L.,George, Clifford,Rice, Kenner C.
, p. 4761 - 4768 (2007/10/03)
We have explored the synthesis of compounds that have good affinity for both μ- and δ-opioid receptors from the (αR,2S,5S) class of diaryldimethylpiperazines. These non-selective compounds were related to opioids that have been found to interact selective
