66852-54-8 Usage
Description
Different sources of media describe the Description of 66852-54-8 differently. You can refer to the following data:
1. Halobetasol propionate is a new ultra-potent topical corticosteroid exhibiting both
antiinflammatory and antihyperplasia properties. The compound is recommended for
the treatment of moderate to severe corticosteroid-responsive dermatoses and appears
to be particularly effective in patients with plaque psoriasis.
2. Halobetasol propionate is a synthetic glucocorticoid. It inhibits dermatitis induced by ultraviolet light in guinea pigs (ED50 = 1.45 μg/animal) and by oxazolone in mice (ED50 = 0.8 μg/animal). Halobetasol propionate also has anti-inflammatory effects on croton oil-induced ear edema in rats (ED50s = 10 μg/ml and 0.5 μg/ear) and mice (ED50s = 1.2 and <0.32 μg/ear after 6 and 24 hours of treatment, respectively). Topical formulations containing halobetasol propionate have been used for inflammatory and pruritic dermatitis.
Chemical Properties
White Solid
Uses
Anti-inflammatory; a dermatologic agent commonly used to treat psoriasis
Brand name
Ultravate (Westwood-Squibb).
Check Digit Verification of cas no
The CAS Registry Mumber 66852-54-8 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 6,6,8,5 and 2 respectively; the second part has 2 digits, 5 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 66852-54:
(7*6)+(6*6)+(5*8)+(4*5)+(3*2)+(2*5)+(1*4)=158
158 % 10 = 8
So 66852-54-8 is a valid CAS Registry Number.
InChI:InChI=1/C25H31ClF2O5/c1-5-33-21(32)24(20(31)12-26)13(2)8-15-16-10-18(27)17-9-14(29)6-7-22(17,3)25(16,28)19(30)11-23(15,24)4/h6-7,9,13,15-16,18-19,30H,5,8,10-12H2,1-4H3/t13-,15-,16-,18-,19-,22-,23-,24+,25-/m0/s1
66852-54-8Relevant articles and documents
A PROCESS FOR PREPARING A CRYSTALLINE FORM OF HALOBETASOL PROPIONATE
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Page/Page column 25, (2008/06/13)
The present invention provides a process for preparing a crystalline form of halobetasol propionate, comprising the step of crystallizing halobetasol propionate from absolute ethanol or a mixture of ethanol and water, wherein the crystalline form of halobetasol propionate is characterized by an x-ray powder diffraction pattern having peaks at 10.0, 11.6, 12.9, 13.4, 14.5, 16.4, 17.6, and 23.5 + 0.2 degrees 2θ.
Method for the preparation of 6alpha-fluoro corticosteroids
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, (2008/06/13)
A method for producing a 6α-fluorinated corticosteroid or derivative thereof by reacting a 17-hydroxy-21-ester epoxide of Formula II with a stereoselective fluorinating agent to stereoselectively form a 21-ester-17-hydroxy 6α-fluorinated compound of Formula VII R1 can be OC(O)—Rd; R4 can be C(O)—Rd; R3 can be H or Rd. Each Rd may be the same or different and is independently selected from (C1-4)alkyl, aryl and heteroaryl. The dashed line can be a single or a double bond. R4 may be, for example, acetyl; R3 may be, for example, alpha or beta methyl; R4 may be, for example, acetate or propionate. The stereoselective fluorinating agent used in the reaction may be, for example, a fluoropyridinium or fluoroquinuclidium compound, for example, Selectfluor?.
Composition for the topical treatment of poison ivy and other forms of contact dermatitis
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, (2008/06/13)
Composition for topical administration comprising (a) a corticosteroid, and (b) a drying agent.
