6686-68-6

Basic information

• Product Name: Benzoic acid, 2-[(4-methoxyphenyl)amino]-5-nitro-
• CAS NO: 6686-68-6
• Molecular Formula: C14H12N2O5
• Molecular Weight: 288.26
• Mol File: 6686-68-6.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: Benzoic acid, 2-[(4-methoxyphenyl)amino]-5-nitro-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzoic acid, 2-[(4-methoxyphenyl)amino]-5-nitro-(6686-68-6)
• EPA Substance Registry System: Benzoic acid, 2-[(4-methoxyphenyl)amino]-5-nitro-(6686-68-6)

Safety Data

• Hazardous Substances Data: 6686-68-6(Hazardous Substances Data)

Upstream product

• 85020-92-4 2-p-anisidino-5-nitro-benzoic acid methyl ester 
• 6942-36-5 methyl 2-bromo-5-nitrobenzoate 
• 943-14-6 2-bromo-5-nitrobenzoic acid 
• 104-92-7 1-bromo-4-methoxy-benzene 
• 616-79-5 2-amino-5-nitro-benzoic acid 
• 118-91-2 ortho-chlorobenzoic acid 
• 7304-32-7 2-fluoro-5-nitrobenzoic acid 
• 104-94-9 4-methoxy-aniline 
• 2516-96-3 2-chloro-5-nitrobenzoic acid 

Downstream Products

• 20440-91-9 4,4’-dimethoxy-4’’-nitrotriphenylamine 
• 857615-98-6 acetic acid-[4-(2-methoxy-7-nitro-acridin-9-ylamino)-anilide] 
• 857614-03-0 (4-ethoxy-phenyl)-(2-methoxy-7-nitro-acridin-9-yl)-amine 
• 857614-06-3 (2-methoxy-7-nitro-acridin-9-yl)-(4-methoxy-phenyl)-amine 
• 100622-84-2 2-[(4-methoxyphenyl)amino]-5-nitrobenzoic acid chloride 
• 102079-64-1 2-p-anisidino-5-nitro-benzoic acid anilide 
• 85020-92-4 2-p-anisidino-5-nitro-benzoic acid methyl ester 
• 33836-67-8 5-amino-2-p-anisidino-benzoic acid 

Relevant articles and documents

Monna, a potent and selective blocker for transmembrane protein with unknown function 16/anoctamin-1

Transmembrane protein with unknown function 16/anoctamin-1 (ANO1) is a protein widely expressed in mammalian tissues, and it has the properties of the classic calcium-activated chloride channel (CaCC). This protein has been implicated in numerous major physiological functions. However, the lack of effective and selective blockers has hindered a detailed study of the physiological functions of this channel. In this study, we have developed a potent and selective blocker for endogenous ANO1 in Xenopus laevis oocytes (xANO1) using a drug screening method we previously established (Oh et al., 2008). We have synthesized a number of anthranilic acid derivatives and have determined the correlation between biological activity and the nature and position of substituents in these derived compounds. A structure-activity relationship revealed novel chemical classes of xANO1 blockers. The derivatives contain a-NO2 group on position 5 of a naphthyl group-substituted anthranilic acid, and they fully blocked xANO1 chloride currents with an IC 5050 of 0.08 μM for xANO1. Selectivity tests revealed that other chloride channels such as bestrophin-1, chloride channel protein 2, and cystic fibrosis transmembrane conductance regulator were not appreciably blocked by 10～30 μM MONNA. The potent and selective blockers for ANO1 identified here should permit pharmacological dissection of ANO1/CaCC function and serve as potential candidates for drug therapy of related diseases such as hypertension, cystic fibrosis, bronchitis, asthma, and hyperalgesia.

2-(4-Methoxyphenoxy)-5-nitro-N-(4-sulfamoylphenyl)benzamide activates Kir6.2/SUR1 KATP channels

2-(4-Methoxyphenoxy)-5-nitro-N-(4-sulfamoylphenyl)benzamide and close analogues inhibit glucose stimulated insulin release through activation of Kir6.2/SUR1 KATP channels of beta cells.