66892-78-2Relevant academic research and scientific papers
Br?nsted Acid Catalyzed Tandem Defunctionalization of Biorenewable Ferulic acid and Derivates into Bio-Catechol
Bal, Mathias,Bomon, Jeroen,Liao, Yuhe,Maes, Bert U. W.,Sels, Bert F.,Sergeyev, Sergey,Van Den Broeck, Elias,Van Speybroeck, Veronique
, p. 3063 - 3068 (2020)
An efficient conversion of biorenewable ferulic acid into bio-catechol has been developed. The transformation comprises two consecutive defunctionalizations of the substrate, that is, C?O (demethylation) and C?C (de-2-carboxyvinylation) bond cleavage, occurring in one step. The process only requires heating of ferulic acid with HCl (or H2SO4) as catalyst in pressurized hot water (250 °C, 50 bar N2). The versatility is shown on a variety of other (biorenewable) substrates yielding up to 84 % di- (catechol, resorcinol, hydroquinone) and trihydroxybenzenes (pyrogallol, hydroxyquinol), in most cases just requiring simple extraction as work-up.
Microbial synthesis of (+)-(3R)-ethyl 3-hydroxy-3-(3,4-dimethoxyphenyl)propionate
Bardot, Valerie,Besse, Pascale,Gelas-Miahle, Yvonne,Remuson, Roland,Veschambre, Henri
, p. 1077 - 1088 (2007/10/03)
From the microbiological reduction of ethyl 3-oxo-3-(3,4-dimethoxyphenyl)-propionate, (+)-(3R)-ethyl 3-hydroxy-3-(3,4-dimethoxyphenyl)propionate was prepared on a quantitative scale. The absolute configuration was assigned by X-ray structural determination of the crystallized camphanate derivative.
