66896-50-2

Upstream product

• 75-07-0 acetaldehyde 
• 585-32-0 2-phenyl-2-propylamine 
• 826-55-1 2-methyl-2-phenylpropionic acid 
• 4747-74-4 α,α-dimethylbenzyl isocyanate 
• 79649-68-6 N-(1-methyl-1phenylethyl)acetamide 

Downstream Products

• 66897-61-8 N-ethyl-N-(2-phenylpropan-2-yl)-benzenesulfonamide 
• 179096-53-8 N-Ethyl-2-methyl-N-(1-methyl-1-phenyl-ethyl)-benzamide 
• 1027196-83-3 C₅₄H₆₈N₂O₄Si 

Relevant academic research and scientific papers

A Copper-Catalyzed Aerobic [1,3]-Nitrogen Shift through Nitrogen-Radical 4-exo-trig Cyclization

A novel radical [1,3]-nitrogen shift catalyzed by copper diacetate under an oxygen atmosphere (1 atm) has been developed for the construction of a diverse range of indole derivatives from α,α-disubstituted benzylamine. In this reaction, oxygen was used as a clean terminal oxidant, and water was produced as the only by-product. Five inert bonds were cleaved, and two C?N bonds and one C?C double bond were constructed in one pot during this transformation. This unique method demonstrated broad application protential for the late-stage modification of biologically active natural products and drugs. Mechanistic investigations indicate that a unique 4-exo-trig cyclization of an aminyl radical onto a phenyl ring is involved in the catalytic cycle.

Bis tertiary amide inhibitors of the HIV-1 protease generated via protein structure-based iterative design

A series of potent nonpeptide inhibitors of the HIV protease have been identified. Using the structure of compound 3 bound to the HIV protease, his tertiary amide inhibitor 9 was designed and prepared. Compound 9 was found to be about 17 times more potent than 3, and the structure of the protein- ligand complex of 9 revealed the inhibitor binds in an inverted binding mode relative to 3. Examination of the protein-ligand complex of 9 suggested several modifications in the P1 and P1' pockets. Through these modifications it was possible to improve the activity of the inhibitors another 100-fold, highlighting the utility of crystallographic feedback in inhibitor design. These compounds were found to have good antiviral activity in cell culture, were selective for the HIV protease, and were orally available in three animal models.