4747-74-4

Basic information

• Product Name: Benzene, (1-isocyanato-1-methylethyl)-
• CAS NO: 4747-74-4
• Molecular Formula: C10H11NO
• Molecular Weight: 161.203
• Mol File: 4747-74-4.mol
• Article Data: 11

Chemical Properties

• CAS DataBase Reference: Benzene, (1-isocyanato-1-methylethyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzene, (1-isocyanato-1-methylethyl)-(4747-74-4)
• EPA Substance Registry System: Benzene, (1-isocyanato-1-methylethyl)-(4747-74-4)

Safety Data

• Hazardous Substances Data: 4747-74-4(Hazardous Substances Data)

Upstream product

• 75-13-8 isocyanic acid 
• 98-83-9 isopropenylbenzene 
• 36293-05-7 2-methyl-2-phenylpropanoyl chloride 
• 107955-92-0 N-hydroxy-2-methyl-2-phenylpropanamide 
• 65864-89-3 C₁₀H₁₁N₃O 
• 623569-70-0 dimethylbenzylisocyanate 
• 32315-10-9 bis(trichloromethyl) carbonate 
• 585-32-0 2-phenyl-2-propylamine 
• 75-44-5 phosgene 
• 826-55-1 2-methyl-2-phenylpropionic acid 

Downstream Products

• 25348-07-6 N,N'-bis-(1-methyl-1-phenyl-ethyl)-urea 
• 58609-76-0 (1-methyl-1-phenyl-ethyl)-urea 
• 819803-48-0 C₁₁H₁₅N₃O₂ 
• 1161825-78-0 3-(1-phenyl-1methylethyl)-4-oxo-3,4-dihydroimidazo[5,1-d][1,2,3,5]tetrazine-8-carboxamide 
• 1198745-91-3 N-(2-phenylpropan-2-yl)morpholine-4-carboxamide 
• 40816-57-7 N-(1-methyl-1-phenyl-ethyl)-N'-phenyl-urea 
• 79649-68-6 N-(1-methyl-1phenylethyl)acetamide 
• 875-30-9 1,3-dimethylindole 
• 66896-50-2 dimethylethylbenzylamine 
• 66896-49-9 N-methylcumylamine 
• 1092694-72-8 N-(1-methyl-1-phenylethyl)-3-(n-butyl)-5,5-dimethyl-4-phenyl-4,5-dihydro-(1H)-pyrazole-1-carboxamide 
• 401524-99-0 5-(α,αdimethylbenzyl)carbamoyloxy-3-(3-trifluoromethyl)phenyl-4-thiazolidinone 
• 72235-67-7 C₁₈H₁₆⁽²⁾H₆N₂ 

Relevant articles and documents

Palladium(II)-Catalyzed C(sp2)-H Carbonylation of Sterically Hindered Amines with Carbon Monoxide

A palladium-catalyzed, amine-directed C(sp2)-H carbonylation of α,α-disubstituted benzylamine under 1 atm of CO for the facile synthesis of sterically hindered benzolactam has been developed. The key to success is the use of 2,2,6,6-tetramethyl-1-piperidinyloxy as the crucial sole oxidant. The synthetic utility of this transformation has been demonstrated by the first concise synthesis of the natural product spiropachysin-20-one.

PRIMARY AMINE DIAZENIUMDIOLATE HETEROCYCLIC DERIVATIVES

A compound having the structure useful for treating hypertension, Pulmonary Arterial Hypertension (PAH), congestive heart failure, conditions resulting from excessive water retention, cardiovascular disease, diabetes, oxidative stress, endothelial dysfunction, cirrhosis, pre-eclampsia, osteoporosis or nephropathy.

3-SUBSTITUTED-4-OXO-3,4-DIHYDRO-IMIDAZO-[5,1-D][1,2,3,5-TETRAZINE-8-CARBOXYLIC ACID AMIDES AND THEIR USE

The present invention pertains generally to the field of therapeutic compounds, and more specifically to certain 3-substituted-4-oxo-3,4-dihydro-imidazo[5,1-d][1,2,3,5]tetrazine-8-carboxylic acid amide (collectively referred to herein as 3TM compounds). The present invention also pertains to pharmaceutical compositions comprising such compounds, and the use of such compounds and compositions, both in vitro and in vivo, to inhibit cell proliferation, and in the treatment of proliferative disorders such as cancer, etc., and methods of preparing such compounds.