66898-40-6

Upstream product

• 77222-66-3 2-Oxo-3-propyl-chroman-3-carboxylic acid ethyl ester 
• 2697-95-2 dibutyryl peroxide 
• 91-64-5 coumarin 
• 107-92-6 butyric acid 
• 1538551-54-0 1,3-dioxoisoindolin-2-yl butyrate 
• 90-02-8 salicylaldehyde 
• 84589-96-8 α-diethylphosphonopentanoic acid 
• 84589-95-7 diethylphosphonopropylketene 
• 136294-63-8 3-Allyl-2-oxo-chroman-3-carboxylic acid ethyl ester 
• 720-72-9 ethyl 2-oxo-3,4-dihydro-2H-chromen-3-carboxylate 
• 2082-59-9 pentanoic anhydride 
• 77202-49-4 3-Propyl-chroman-2-one 
• 96600-98-5 3-allylchroman-2-one 
• 67683-19-6 (diethoxyphosphinyl)phenylketene 

Relevant academic research and scientific papers

Carbon-13 NMR Signals of Some Substituted Indanones, Tetralones and Benzo-α-pyrones, β-substituted β-Phenylpropionic Acids and Related Compounds

13C spectral assignments for 3-methyl-1-indanone, 3-ethyl-1-indanone, 3-n-propyl-1-indanone, 3-phenyl-1-indanone, 3-phenyl-1-tetralone, 3- and/or 4-substituted benzo-α-pyrones and dihydrobenzo-α-pyrones, together with those for 3-phenylbutyric acid, 3-phenylvaleric acid, 3-phenylcaproic acid, 3,3-diphenylpropanoic acid, 3,4-diphenylbutyric acid, their 2-carboxy derivatives and the ethyl esters of the 2-carbethoxy derivatives are reported.

Preparation method of C-3-position alkyl-substituted coumarin derivative

The invention discloses a synthesis method of a C-3-position alkyl-substituted coumarin derivative. The method comprises the steps of dissolving a coumarin derivative shown as a formula (I) and an alkyl peroxide shown as a formula (II) in an organic solve

Iron-Catalyzed Regioselective Decarboxylative Alkylation of Coumarins and Chromones with Alkyl Diacyl Peroxides

A facile iron-catalyzed decarboxylative radical coupling of alkyl diacyl peroxides with coumarins or chromones has been developed, affording a highly efficient approach to synthesize a variety of α-alkylated coumarins and β-alkylated chromones. The reaction proceeded smoothly without adding any ligand or additive and provided the corresponding products containing a wide scope of functional groups in moderate to excellent yields. This protocol was highlighted by its high regioselectivity, readily available starting materials, and operational simplicity.

Direct C-3 alkylation of coumarins via decarboxylative coupling with carboxylic acids

A new method for selective C-3 alkylation of coumarins using carboxylic acids as alkyl sources is reported. This process offers a practical method for the facile construction of 3-alkyl coumarins with a broad substrate scope. The reaction works under metal-free and aqueous media and both cyclic and acyclic aliphatic carboxylic acids participate in this radical C-C cross coupling reaction.

Visible-light-induced regioselective alkylation of coumarins via decarboxylative coupling with N-hydroxyphthalimide esters

An efficient photocatalytic decarboxylative 3-position alkylation of coumarins by using alkyl N-hydroxyphthalimide esters as alkylation reagents has been developed. A variety of NHP esters derived from aliphatic carboxylic acids (primary, secondary, and tertiary) has been proved to be tolerated for this decarboxylation process, affording a broad scope of 3-alkylated coumarin derivatives in moderate to excellent yields. This protocol was highlighted by its mild conditions, readily available starting materials, operational simplicity, and wide functional group tolerance.

Synthesis method of C-3 alkyl substituted coumarin derivative

The invention discloses a synthesis method of a C-3 alkyl substituted coumarin derivative. The synthesis method comprises the following steps: dissolving a coumarin derivative shown as a formula (I),an N-alkyloxyphthalimide compound shown as a formula (II), a photocatalyst and a proton acid in an organic solvent; reacting under visible light irradiation at a temperature of 20 to 60 DEG C for 3 to36 hours; after the reaction is finished, performing post-treatment on a reaction system to obtain a target product of the C-3 alkyl substituted coumarin derivative shown as a formula (III), whereinthe reaction formulas are shown in the description; in the formulas (I) and the formula (III), the substituent R1 is H, methyl, methoxy, fluorine, chlorine or bromine; in the formula (II) and the formula (III), the substituent R2 is linear alkyl or naphthenic alkyl of with 1 to 8 carbon atoms. The synthesis method realizes the C-3alkylation of coumarin with light as reaction energy, makes the reaction safer, more environmentally friendly and cheaper, expands the application range of the reaction substrate, and enriches the synthesis method of a C-3 substituted coumarin compound.