669002-47-5Relevant articles and documents
Novel pyrazolopiperazinone- and pyrrolopiperazinone-based MCH-R1 antagonists
Meyers, Kenneth M.,Mendez-Andino, Jose,Colson, Anny-Odile,Hu, X. Eric,Wos, John A.,Mitchell, Maria C.,Hodge, Karen,Howard, Jeremy,Paris, Jennifer L.,Dowty, Martin E.,Obringer, Cindy M.,Reizes, Ofer
, p. 657 - 661 (2007/10/03)
The synthesis and biological testing of novel classes of potent melanin-concentrating hormone (MCH-R1) antagonists based on pyrazolopiperazinone and pyrrolopiperazinone scaffolds are described.
Beta-ketoamide compounds with MCH antagonistic activity
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Page/Page column 32, (2008/06/13)
Compounds of formula I wherein the groups and residues A, B, b, X, Y, Z, R1, R2, R3, R5a and R5b have the meanings given in claim 1. The invention further relates to pharmaceutical compositions containing at least one amide according to the invention. As a result of their MCH-receptor antagonistic activity the pharmaceutical compositions according to the invention are suitable for the treatment of metabolic disorders and/or eating disorders, particularly obesity, bulimia, anorexia, hyperphagia, and diabetes.