912641-08-8

Upstream product

• 637311-69-4 (3-endo)-3-(4-chlorophenyl)-8-azabicyclo[3.2.1]octan-3-ol 
• 32499-64-2 N-carbethoxytropinone 
• 83393-32-2 8-ethoxycarbonyl-3β-(4-chlorophenyl)-3α-hydroxy-8-azabicyclo[3.2.1]octane 
• 1204302-64-6 8-ethoxycarbonyl-3-(4-chlorophenyl)-8-azabicyclo[3.2.1]oct-2-ene 
• 106-39-8 bromochlorobenzene 
• 22932-21-4 3-(4-chloro-phenyl)-8-methyl-8-aza-bicyclo[3.2.1]oct-2-ene 
• 22932-27-0 3-(4-chloro-phenyl)-8-methyl-8-aza-bicyclo[3.2.1]octan-3-ol 
• 532-24-1 tropinone 

Downstream Products

• 1204302-69-1 3-(4-chlorophenyl)-2-nortropene oxalate 
• 780020-06-6 1-(4-Fluoro-phenyl)-4-((1R,3S,5S)-3-phenyl-8-aza-bicyclo[3.2.1]oct-8-yl)-butan-1-one 
• 669002-98-6 3-phenyl-8-aza-bicyclo[3.2.1]octane 

Relevant academic research and scientific papers

Haloperidol: Towards further understanding of the structural contributions of its pharmacophoric elements at D2-like receptors

An attempt to understand the pharmacophore-relevant position of the alcoholic moiety in haloperidol and the contributions of other pharmacophoric elements led to the re-synthesis of its tropane analogue (compound 2). An analysis of the binding data sugges

Synthesis and monoamine transporter affinity of 3α-arylmethoxy-3β-arylnortropanes

A series of 3-arylnortrop-2-enes and 3α-arylmethoxy-3β-arylnortropanes were synthesized and evaluated for binding affinity at monoamine transporters. The 3-(3,4-dichlorophenyl)nortrop-2-ene (6e) exhibited high affinity for the SERT (Ki = 0.3 nM

Azabicycloalkane derivatives for use as serotonin reuptake inhibitors and 5ht2a antagonists

The present invention is directed to a compound of the formula (I): and pharmaceutically acceptable salts thereof, wherein R1, R2, Y, U, W, k, A, E, V, R4 and R5 are as defined herein, pharmaceutical compositions thereof, and methods of use thereof in the inhibition of serotonin reuptake, the inhibition of the binding of 5-HT2A serotonin receptors and the treatment of diseases, conditions or disorders of the central nervous system. Further, the present invention is also directed to methods for the preparation of compounds of formula (I) and intermediates useful therefor.

8-azabicyclo[3.2.1.]oct-2-ene derivatives, their preparation and use

PCT No. PCT/EP96/04449 Sec. 371 Date May 18, 1998 Sec. 102(e) Date May 18, 1998 PCT Filed Oct. 11, 1996 PCT Pub. No. WO97/13770 PCT Pub. Date Apr. 17, 1997A compound having the formula, or any of its enantiomers or any mixture thereof, or a pharmaceutical