669003-76-3

Upstream product

• 852287-35-5 {2-[4-(2-chloro-ethoxy)-benzyloxy]-phenyl}-(2-chloro-9H-purin-6-yl)-amine 
• 778603-84-2 C₁₅H₁₄ClNO₄ 
• 137-43-9 Cyclopentyl bromide 
• 109-01-3 1-methyl-piperazine 
• 669003-75-2 [2-(3-chloro-propoxy)-phenyl]-(2-chloro-9-cyclopentyl-purin-6-yl)-amine 
• 778603-78-4 2-[4-(2-chloro-ethoxy)-benzyloxy]-phenylamine 

Relevant academic research and scientific papers

HETEREOARYL NITRILE DERIVATIVES

The invention provides compounds of Formula (I) or a pharmaceutically acceptable salt or ester thereof wherein the symbols have meaning as defined, which are inhibitors of cathepsin K and find use pharmaceutically for treatment of diseases and medical con

Novel purine nitrile derived inhibitors of the cysteine protease cathepsin K

Starting from the high-throughput screening hit 1a, novel cathepsin K inhibitors have been developed based on a purine scaffold. High-resolution X-ray structures of several derivatives have revealed the binding mode of these unique cysteine protease inhib