778603-84-2

Upstream product

• 623-05-2 (4-hydroxyphenyl)methanol 
• 88-75-5 2-hydroxynitrobenzene 
• 111728-87-1 (4-(2-chloroethoxy)phenyl)methan-1-ol 

Downstream Products

• 778603-85-3 (2-chloro-9-cyclopentyl-9H-purin-6-yl)-(2-{4-[2-(4-methyl-piperazin-1-yl)-ethoxy]-benzyloxy}-phenyl)-amine 
• 1026315-38-7 (2-chloro-9-cyclopentyl-9H-purin-6-yl)-(2-{4-[2-(2-methoxy-ethylamino)-ethoxy]-benzyloxy}-phenyl)-amine 
• 669003-76-3 (2-chloro-9-cyclopentyl-purin-6-yl)-{2-[3-(4-methyl-piperazin-1-yl)-propoxy]-phenyl}amine 
• 778603-79-5 (2-chloro-9-cyclopentyl-9H-purin-6-yl)-{2-[4-(2-chloro-ethoxy)-benzyloxy]-phenyl}-amine 
• 1026001-88-6 (2-chloro-9-cyclopentyl-9H-purin-6-yl)-[2-(3-imidazol-1-yl-propoxy)-phenyl]-amine 
• 852287-35-5 {2-[4-(2-chloro-ethoxy)-benzyloxy]-phenyl}-(2-chloro-9H-purin-6-yl)-amine 
• 778603-78-4 2-[4-(2-chloro-ethoxy)-benzyloxy]-phenylamine 

Relevant academic research and scientific papers

Novel purine nitrile derived inhibitors of the cysteine protease cathepsin K

Starting from the high-throughput screening hit 1a, novel cathepsin K inhibitors have been developed based on a purine scaffold. High-resolution X-ray structures of several derivatives have revealed the binding mode of these unique cysteine protease inhib