669068-63-7

Upstream product

• 658-99-1 (3,4-difluorophenyl)acetonitrile 
• 55-86-7 mechlorethamine hydrochloride 

Downstream Products

• 906369-62-8 4-(3,4-difluoro-phenyl)-4-(methanesulfonylamino-methyl)-piperidine-1-carboxylic acid tert-butyl ester 
• 906369-56-0 4-cyano-4-(3,4-difluoro-phenyl)-piperidine-1-carboxylic acid tert-butyl ester 

Relevant academic research and scientific papers

Preparation of 2,3-dihydro-1H-spiro[isoquinoline-4,4′-piperidine] via an N-sulfonyl Pictet-Spengler reaction

A high yielding synthesis of variously substituted 2,3-dihydro-1H-spiro[isoquinoline-4,4′-piperidine] is reported. N-(2-nitrophenyl)sulfonyl was successfully used as both an activating and protecting group for the key Pictet-Spengler reaction.

NAPHTHAMIDE DERIVATIVES AND THEIR USE

Compounds having the following structure wherein R1, R2, R3, R4, m and n are as defined in the specification, in vivo-hydrolysable precursors thereof, pharmaceutically-acceptable salts thereof, the use in therapy and pharmaceutical compositions and methods of treatment using the same.