669068-74-0

Upstream product

• 258500-80-0 4-(4-fluorophenyl)-1-methylpiperidine-4-carbonitrile 
• 55-86-7 mechlorethamine hydrochloride 
• 459-22-3 4-fluorophenylacetonitrile 
• 256951-79-8 4-(4-fluorophenyl)-tert-butoxycarbonylpiperidine-4-carbonitrile 

Downstream Products

• 906369-59-3 4-(4-fluoro-phenyl)-4-(methanesulfonylamino-methyl)-piperidine-1-carboxylic acid tert-butyl ester 
• 719276-18-3 1-N-Boc-4-(4-fluorophenyl)-4-(3-(3-cyanonaphth-1-yl)-(2-azaprop-1-yl))piperidine 

Relevant academic research and scientific papers

THIAZOLYL COMPOUNDS USEFUL AS KINASE INHIBITORS

The invention provides compounds of formula (I) and pharmaceutically acceptable salts thereof. The formula I thiazolyl compounds inhibit tyrosine kinase activity thereby making them useful as anticancer agents and for the treatment of Alzheimer's disease

Preparation of 2,3-dihydro-1H-spiro[isoquinoline-4,4′-piperidine] via an N-sulfonyl Pictet-Spengler reaction

A high yielding synthesis of variously substituted 2,3-dihydro-1H-spiro[isoquinoline-4,4′-piperidine] is reported. N-(2-nitrophenyl)sulfonyl was successfully used as both an activating and protecting group for the key Pictet-Spengler reaction.

NAPHTHAMIDE DERIVATIVES AND THEIR USE

Compounds having the following structure wherein R1, R2, R3, R4, m and n are as defined in the specification, in vivo-hydrolysable precursors thereof, pharmaceutically-acceptable salts thereof, the use in therapy and pharmaceutical compositions and methods of treatment using the same.

PIPERIDINE AMINE COMPOUNDS AND THEIR USE

Compounds having the formula[Chemical formula should be inserted here. Please see paper copy] wherein R1, R2, R3, R6, R7 and Ar are as defined in the specification, in vivo-hydrolysable precursors the