66909-34-0

Usage

Uses

2-Chloro-5-methylnicotinonitrile

Upstream product

• 884494-95-5 5-methyl-nicotinic acid chloride 
• 3222-49-9 5-methylnicotinic acid 
• 52833-34-8 propylidenemalonitrile 
• 68-12-2 N,N-dimethyl-formamide 

Downstream Products

• 65169-45-1 2-chloro-5-methylnicotinamide 
• 65169-43-9 2-chloro-5-methylnicotinic acid methyl ester 

Relevant academic research and scientific papers

COMPOUNDS AND USE THEREOF IN THE EXPANSION OF STEM CELLS AND/OR PROGENITOR CELLS

The invention relates to compounds of formula I and pharmaceutical compositions containing them. Also, the invention relates to methods for expanding stem cells and/or progenitor cells and methods for treating a hematopoietic disorder/malignancy, and autoimmune disease and/or an inherited immunodeficient disease (I).

SULFONYL AMIDE DERIVATIVES FOR THE TREATMENT OF ABNORMAL CELL GROWTH

The present invention relates to a compound of the formula I wherein R1 to R6, A, B, n and m are as defined herein. Such novel sulfonyl amide derivatives are useful in the treatment of abnormal cell growth, such as cancer, in mammals. This invention also relates to a method of using such compounds in the treatment of abnormal cell growth in mammals, especially humans, and to pharmaceutical compositions containing such compounds.

A one-pot synthesis of 2-chloronicotinonitriles and fused 2-chloro-3-cyanopyridines

2-Chloronicotinonitriles (2a-d) and fused bi- and tricyclo-2-chloro-3-cyanopyridines (2e-h) are obtained from alkylidenemalononitriles (1a-h) by Vilsmeier reaction.Generation in situ of an aldehyde equivalent species in the Vilsmeier reaction at the γ-carbon with respect to the nitrile carbon of the alkylidenemalononitriles, followed by cylization, both occurring in one-pot, are presumed to be involved in the pyridoannulation.