66909-34-0

Basic information

• Product Name: 2-CHLORO-5-METHYL-NICOTINONITRILE
• Synonyms: 2-CHLORO-5-METHYL-NICOTINONITRILE;2-chloro-5-methyl-3-Pyridinecarbonitrile
• CAS NO: 66909-34-0
• Molecular Formula: C₇H₅ClN₂
• Molecular Weight: 152.581
• Mol File: 66909-34-0.mol
• Article Data: 3

Chemical Properties

• Melting Point: 117 °C(Solv: water (7732-18-5); ethanol (64-17-5))
• Boiling Point: 290.3±35.0 °C(Predicted)
• Appearance: /
• Density: 1.26±0.1 g/cm3(Predicted)
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• PKA: -1.77±0.10(Predicted)
• CAS DataBase Reference: 2-CHLORO-5-METHYL-NICOTINONITRILE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-CHLORO-5-METHYL-NICOTINONITRILE(66909-34-0)
• EPA Substance Registry System: 2-CHLORO-5-METHYL-NICOTINONITRILE(66909-34-0)

Safety Data

• Statements: 41
• Safety Statements: 26-39
• RIDADR: UN 2811 6.1 / PGIII
• WGK Germany: 3
• HazardClass: IRRITANT
• Hazardous Substances Data: 66909-34-0(Hazardous Substances Data)

Usage

Uses

2-Chloro-5-methylnicotinonitrile

Upstream product

• 884494-95-5 5-methyl-nicotinic acid chloride 
• 3222-49-9 5-methylnicotinic acid 
• 52833-34-8 propylidenemalonitrile 
• 68-12-2 N,N-dimethyl-formamide 

Downstream Products

• 65169-43-9 2-chloro-5-methylnicotinic acid methyl ester 
• 65169-45-1 2-chloro-5-methylnicotinamide 

Relevant articles and documents

COMPOUNDS AND USE THEREOF IN THE EXPANSION OF STEM CELLS AND/OR PROGENITOR CELLS

The invention relates to compounds of formula I and pharmaceutical compositions containing them. Also, the invention relates to methods for expanding stem cells and/or progenitor cells and methods for treating a hematopoietic disorder/malignancy, and autoimmune disease and/or an inherited immunodeficient disease (I).

A one-pot synthesis of 2-chloronicotinonitriles and fused 2-chloro-3-cyanopyridines

2-Chloronicotinonitriles (2a-d) and fused bi- and tricyclo-2-chloro-3-cyanopyridines (2e-h) are obtained from alkylidenemalononitriles (1a-h) by Vilsmeier reaction.Generation in situ of an aldehyde equivalent species in the Vilsmeier reaction at the γ-carbon with respect to the nitrile carbon of the alkylidenemalononitriles, followed by cylization, both occurring in one-pot, are presumed to be involved in the pyridoannulation.