65169-43-9

Usage

Uses

Used in Pharmaceutical Industry:
2-CHLORO-5-METHYL-NICOTINIC ACID METHYL ESTER is used as a pharmaceutical intermediate for the synthesis of drugs. Its unique chemical structure allows it to be a key component in the development of new medications, potentially offering novel therapeutic options for various health conditions.
Used in Chemical Research and Development:
In the field of chemical research and development, 2-CHLORO-5-METHYL-NICOTINIC ACID METHYL ESTER serves as a valuable compound for exploring its properties and potential applications. Researchers can investigate its reactivity, stability, and interactions with other molecules, which may lead to the discovery of new chemical reactions or processes that can be applied in various industries.
Used in Drug Synthesis:
2-CHLORO-5-METHYL-NICOTINIC ACID METHYL ESTER is used as a building block in the synthesis of complex drug molecules. Its presence in the molecular structure can impart specific pharmacological properties to the final drug product, making it a crucial component in the development of innovative therapeutic agents.
Used in Medicinal Chemistry:
In medicinal chemistry, 2-CHLORO-5-METHYL-NICOTINIC ACID METHYL ESTER is utilized for the design and optimization of drug candidates. Its unique functional groups and structural features can be manipulated to enhance the potency, selectivity, and pharmacokinetic properties of drug molecules, ultimately leading to the development of more effective and safer medications.

Upstream product

• 66909-34-0 2-chloro-5-methylpyridine-3-carbonitrile 
• 67-56-1 methanol 
• 66909-30-6 2-chloro-5-methyl-3-pyridinecarboxylic acid 
• 13061-96-6 dihydroxy-methyl-borane 
• 78686-79-0 methyl 2-chloro-5-bromonicotinate 
• 65169-45-1 2-chloro-5-methylnicotinamide 

Downstream Products

• 66909-30-6 2-chloro-5-methyl-3-pyridinecarboxylic acid 
• 188797-88-8 methyl 2-phenylpyridine-3-carboxylate 

Relevant academic research and scientific papers

Kras-G12C inhibitor heterocyclic compounds

The invention relates to Kras-G12C inhibitor heterocyclic compounds and a preparation method thereof, and application of the compounds in prevention and treatment of tumor diseases such as lung cancer, colorectal cancer and pancreatic cancer. In the preparation process, the compounds provided by the invention are obtained through a series of reactions such as a condensation reaction, an intramolecular cyclization reaction, a chlorination reaction, an SN2 reaction, a coupling reaction, deprotection and the like.

AMINO NICOTINIC AND ISONICOTINIC ACID DERIVATIVES AS DHODH INHIBITORS

A compound of formula (I) wherein : - one of the groups G1represents a nitrogen atom or a group CRc and the other represents a group CRc; - G2 represents a nitrogen atom or a group CRd; - R1 represents a group selected from hydrogen atoms, halogen atoms, C1-4 alkyl groups which may be optionally substituted by 1, 2 or 3 substituents selected from halogen atoms and hydroxy groups, and C3-8 cycloalkyl groups which may be optionally substituted by 1, 2 or 3 substituents selected from halogen atoms and hydroxy groups; - R2 represents a group selected from hydrogen atoms, halogen atoms, hydroxyl groups, C1-4 alkyl groups which may be optionally substituted by 1, 2 or 3 substituents selected from halogen atoms and hydroxy groups, C1-4 alkoxy groups which may be optionally substituted by 1, 2 or 3 substituents selected from halogen atoms and hydroxy groups, and C3-8 cycloalkyl groups which may be optionally substituted by 1, 2 or 3 substituents selected from halogen atoms and hydroxy groups; - Ra, Rb and Rc independently represent groups selected from hydrogen atoms, halogen atoms, C1-4 alkyl groups which may be optionally substituted by 1, 2 or 3 substituents selected from halogen atoms and hydroxy groups, and C1-4alkoxy groups which may be optionally substituted by 1, 2 or 3 substituents selected from halogen atoms and hydroxy groups; - Rd represents a group selected from hydrogen atoms, halogen atoms, hydroxyl groups, C1-4 alkyl groups which may be optionally substituted by 1, 2 or 3 substituents selected from halogen atoms and hydroxy groups, and C1-4 alkoxy groups which may be optionally substituted by 1, 2 or 3 substituents selected from halogen atoms and hydroxy groups, and C3-8 cycloalkoxy groups which may be optionally substituted by 1, 2 or 3 substituents selected from halogen atoms and hydroxy groups; - one of the groups G3 and G4 is a nitrogen atom and the other is a CH group; - M is a hydrogen atom or an pharmaceutically acceptable cation with the proviso that, when at least one of the groups Ra and Rb represent a hydrogen atom and G2 is a group CRd, then Rd represents a groups selected from C1-4 alkoxy groups which may be optionally substituted by 1, 2 or 3 substituents selected from halogen atoms and hydroxy groups, C3-8 cycloalkoxy groups which may be optionally substituted by 1, 2 or 3 substituents selected from halogen atoms and hydroxy groups; and the pharmaceutically acceptable salts and N-oxides thereof.

ACYLATED SPIROPIPERIDINE DERIVATIVES AS MELANOCORTIN-4 RECEPTOR MODULATORS

Certain novel N-acylated spiropiperidine derivatives are ligands of the human melanocortin receptor(s) and, in particular, are selective ligands of the human melanocortin-4 receptor (MC-4R). They are therefore useful for the treatment, control, or prevention of diseases and disorders responsive to the modulation of MC-4R, such as obesity, diabetes, nicotine addiction, alcoholism, sexual dysfunction, including erectile dysfunction and female sexual dysfunction.

Methyl, trifluoromethyl, and methoxycarbonyl - Introduction to the fifth position on the pyridine ring of chloronicotinyl insecticide imidacloprid

Imidacloprid is the first chloronicotinyl insecticide and is currently the largest-selling insecticide worldwide. As a project to find its variants of different insecticidal spectra, derivatives substituted with methyl, trifluoromethyl, and methoxy-carbonyl at the fifth position on the pyridine ring of imidacloprid were prepared. Copyright Taylor & Francis Group, LLC.

Preparation of 2-chloropyridine 3-carboxylic acid esters

2-chloropyridine 3-carboxylic acid esters are prepared by cyclization of 1,3-butadiene derivatives in the presence of hydrogen chloride.