66909-36-2

Basic information

• Product Name: 6-chloro-2-methylnicotinonitrile
• Synonyms: 6-chloro-2-methylnicotinonitrile;6-CHLORO-2-METHYLPYRIDINE-3-CARBONITRILE;6-chloro-3-isocyano-2-methylpyridine;6-chloro-3-cyano-2-methylpyridine;6-Chloro-3-cyanopicoline;6-chloro-2-Methyl-3-pyridinecarbonitrile;2-Methyl pyridine-3-base-6-chlorine cyanide
• CAS NO: 66909-36-2
• Molecular Formula: C₇H₅ClN₂
• Molecular Weight: 152.58
• EINECS: -0
• Product Categories: Pyridine series
• Mol File: 66909-36-2.mol

Chemical Properties

• Melting Point: 106-110 °C
• Boiling Point: 246.462 °C at 760 mmHg
• Flash Point: 102.857 °C
• Appearance: /
• Density: 1.269 g/cm³
• Vapor Pressure: 0.027mmHg at 25°C
• Refractive Index: 1.555
• Storage Temp.: 2-8°C
• PKA: -2.60±0.10(Predicted)
• CAS DataBase Reference: 6-chloro-2-methylnicotinonitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 6-chloro-2-methylnicotinonitrile(66909-36-2)
• EPA Substance Registry System: 6-chloro-2-methylnicotinonitrile(66909-36-2)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 66909-36-2(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
6-chloro-2-methylnicotinonitrile is used as an intermediate in the synthesis of various pharmaceuticals, contributing to the development of new drugs due to its ability to undergo multiple chemical transformations.
Used in Agrochemical Industry:
In the agrochemical sector, 6-chloro-2-methylnicotinonitrile is utilized as a key component in the production of insecticides and herbicides, enhancing the effectiveness of these products in controlling pests and unwanted plant growth.
Used in Organic Synthesis:
6-chloro-2-methylnicotinonitrile is employed as a versatile building block in organic synthesis, allowing for the creation of a wide range of organic compounds for various applications across different industries.

InChI:InChI=1/C7H5ClN2/c1-5-6(4-9)2-3-7(8)10-5/h2-3H,1H3

Upstream product

• 41877-40-1 6-hydroxy-2-methylpyridine-3-carbonitrile 
• 824-72-6 P,P-dichlorophenylphosphine oxide 
• 1336-21-6 ammonium hydroxide 
• 41877-40-1 1,6-Dihydro-2-methyl-6-oxo-3-pyridinecarbonitrile 

Downstream Products

• 116986-12-0 2-(bromomethyl)nicotinonitrile 
• 1721-23-9 2-methyl-nicotinonitrile 

Relevant articles and documents

A facile and green synthesis of a naphthyridine derivative: A novel hedgehog pathway modulator

A green and highly efficient synthesis of a naphthyridine derivative, a novel hedgehog pathway modulator, in high yield and purity from inexpensive starting materials is described. The key step involves an acid-promoted aryl amination reaction of aniline

FURO[3,2-B]PYRIDINE COMPOUNDS USEFUL AS INHIBITORS OF THE PAR-2 SIGNALING PATHWAY

Disclosed are chemical entities which are compounds of Formula (I): (I) and pharmaceutically acceptable salts thereof, wherein A, R1, R2, E, n and Z are as defined herein. These chemical entities are useful as inhibitors of the PAR-2 signaling pathway. These chemical entities and pharmaceutically acceptable compositions comprising such chemical entities can be employed for treating various diseases, disorders, and conditions.

One-Step Synthetic Access to Isosteric and Potent Anticancer Nitrogen Heterocycles with the Benzo[c]phenanthridine Scaffold

A versatile one-step two-component cyclization to build new tetracyclic nitrogen heterocycles is described. Ortho-methylhetarenecarbonitrile components were condensed with aldehydes to access a large library of differently substituted ring systems. The heterocyclic core can be easily modified by variation of the position of the endocyclic nitrogen atom in the o-methylhetarenecarbonitrile substrate. The manner of the nucleophilic attack that leads to the condensation can be triggered by different electron-density distribution in the molecule induced by the position of the nitrogen atom. Taking this into account, there is an electronic preference that leads to either pyridophenanthrolines or the corresponding pyridoazacarbazoles as the main products. We demonstrate the high antitumor potential of some of our synthesized heterocycles, which is strongly dependent on the substitution pattern introduced through the aldehyde component. The position and number of endocyclic nitrogen atoms play an important role regarding cytotoxicity of the studied compounds. Isosteric nitrogen heterocycles: A large library of heterocycles, some possessing promising anticancer properties, with different substitution patterns is accessible by a facile one-step cyclization method through application of different aldehydes and distinct o-methylhetarenecarbonitrile components with diverse numbers of nitrogen atoms at various positions in the ring (see scheme).

AZAINDENOISOQUINOLINE TOPOISOMERASE I INHIBITORS

The invention described herein pertains to substituted azaindenoisoquinoline compounds, in particular 7-, 8-, 9-, and 10-azaindenoisoquinoline compounds, which are inhibitors of topoisomerase I, processes and intermediates for their syntheses, pharmaceutical compositions of the compounds, and methods of using them in the treatment of cancer.

Azaindenoisoquinolines as topoisomerase i inhibitors and potential anticancer agents: A systematic study of structure-activity relationships

A comprehensive study of a series of azaindenoisoquinoline topoisomerase I (Top1) inhibitors is reported. The synthetic pathways have been developed to prepare 7-, 8-, 9-, and 10-azaindenoisoquinolines. The present study shows that 7-azaindenoisoquinolines possess the greatest Top1 inhibitory activity and cytotoxicity. Additionally, the introduction of a methoxy group into the D-ring of 7-azaindenoisoquinolines improved their biological activities, leading to new lead molecules for further development. A series of QM calculations were performed on the model "sandwich" complexes of azaindenoisoquinolines with flanking DNA base pairs from the Drug-Top1-DNA ternary complex. The results of these calculations demonstrate how changes in two forces contributing to the π-π stacking (dispersion and charge-transfer interactions) affect the binding of the drug to the Top1-DNA cleavage complex and thus modulate the drug's Top1 inhibitory activity.

SUBSTITUTED PIPERIDINES AS CCR3 ANTAGONISTS

Object of the present invention are novel substituted compounds of the formula 1, wherein A, R1, R2, R3 and R4 are defined as in the description. Another object of the present invention is to provide antagonists of CCR3, more particularly to provide pharmaceutical compositions comprising a pharmaceutically acceptable carrier and a therapeutically effective amount of at least one of the compounds of the present invention or a pharmaceutically acceptable salt thereof.

Synthesis of 3-methyl and 7-methyl regio isomers of medorinone

Reaction of 3-aminocrotononitrile (2) with methyl methacrylate (3) and methyl 2-propynolate (9) led to the formation of 1,4,5,6-tetrahydro-2,5-dimethyl-6-oxo-3-pyridinecarbonitrile (4) and 1,6-dihydro-2-methyl-6-oxo-3-pyridinecarbonitrile (10), respectively. Condensation of 4 with Bredereck's reagent [bis(dimethylamino)tert-butoxymethane], and that of 6-methoxy-2-methyl-3-pyridinecarbonitrile (12) with N,N-dimethylacetamide dimethyl acetal gave the corresponding enamines 5 and 13 which in turn were cyclized with hydrogen bromide to bromonaphthyridinones 6 and 14, respectively. Debromination of 6 followed by dehydrogenation gave 3-methyl-1,6-naphthyridin-2(1H)-one (8). Debromination of 14 with catalytic reduction gave 7-methyl-1,6-naphthyridin-2(1H)-one (15).

Pyridine and related aza heterocycle derivatives as cardiovascular agents

Novel pharmaceutical compounds and compositions having nitrogen containing ring systems which may be represented by the following structural formula: wherein R1 or R3 is a moiety of the formula: wherein R6 is selected from either hydrogen or acetyl; R7 is selected from 2, 3 or 4-pyridyl or 1-imidazolyl and Q is -(CH2)n, where n is an integer from 1 to 5 and R1 and R2, R2 and R3, R3 and R4 or R4 and R5 taken together may be -CH=CH-CH=CH-. The compounds and compositions are useful as inhibitors of thromboxane synthetase and in the treatment of hypertension and arrythmia in mammals.