66922-06-3Relevant articles and documents
Cobalt-Catalyzed Cross-Coupling of Functionalized Alkylzinc Reagents with (Hetero)Aryl Halides
Grokenberger, Lucie,Hammann, Jeffrey M.,Karaghiosoff, Konstantin,Knochel, Paul,Lutter, Ferdinand H.,Spie?, Philipp
supporting information, p. 5546 - 5550 (2020/02/26)
A combination of 10 % CoCl2 and 20 % 2,2′-bipyridine ligands enables cross-coupling of functionalized primary and secondary alkylzinc reagents with various (hetero)aryl halides. Couplings with 1,3- and 1,4-substituted cycloalkylzinc reagents proceeded diastereoselectively leading to functionalized heterocycles with high diastereoselectivities of up to 98:2. Furthermore, alkynyl bromides react with primary and secondary alkylzinc reagents providing the alkylated alkynes.