66932-96-5

Usage

Uses

Used in Pharmaceutical Industry:
2-CHLORO-N-(3,5-DIMETHOXY-PHENYL)-ACETAMIDE is used as a building block for the synthesis of various drugs and organic compounds, contributing to the development of new medications and therapies.
Used in Research Industry:
2-CHLORO-N-(3,5-DIMETHOXY-PHENYL)-ACETAMIDE is used as a research compound for studying its potential biological activities, such as antimicrobial and anti-inflammatory properties, and its potential applications in the treatment of various diseases and conditions.
Used in Medicinal Chemistry:
2-CHLORO-N-(3,5-DIMETHOXY-PHENYL)-ACETAMIDE is used as a valuable and versatile chemical compound in the field of medicinal chemistry, aiding in the advancement of drug discovery and development.

InChI:InChI=1/C10H12ClNO3/c1-14-8-3-7(12-10(13)6-11)4-9(5-8)15-2/h3-5H,6H2,1-2H3,(H,12,13)

Upstream product

• 630121-37-8 2-chloro-N-(3,5-dimethoxyphenyl)aniline 
• 79-04-9 chloroacetyl chloride 
• 10272-07-8 3.5-dimethoxyaniline 

Downstream Products

• 701259-52-1 N-(3,5-dimethoxyphenyl)-2-(4-nitrophenoxy)acetamide 
• 936633-11-3 2-(4-aminophenoxy)-N-(3,5-dimethoxyphenyl)acetamide 
• 936632-74-5 1-deoxy-1-(6-{4-[(3,5-dimethoxyphenylcarbamoyl)methoxy]phenylamino}-9H-purin-9-yl)-N-ethyl-2,3-O-(1-methylethylidene)-β-D-ribofuranuronamide 

Relevant academic research and scientific papers

A convenient modified synthesis of 5-pyridinyl-1,3,4-thiadiazole-2-carboxamides

A general one-pot procedure is developed for the synthesis of 5-pyridinyl-1,3,4-thiadiazole-2-carboxamides by the reaction of pyridine carboxaldehydes with oxamic acid thiohydrazides. (Figure Presented).

Small-Molecule Choline Kinase Inhibitors as Anti-Cancer Therapeutics

Small molecule choline kinase inhibitors having the following formula: are provided herein. Also provided herein are pharmaceutical compositions containing Formula I compounds, together with methods of treating cancer, methods of inhibiting choline kinase enzymatic activity, and methods of treating tumors by administering an effective amount of a Formula I compound.

N6-[(Hetero)aryl/(cyclo)alkyl-carbamoyl-methoxy-phenyl]-(2-chloro)-5′-N-ethylcarboxamido-adenosines: The first example of adenosine-related structures with potent agonist activity at the human A2B adenosine receptor

A new series of N6-[(hetero)aryl/(cyclo)alkyl-carbamoyl-methoxy-phenyl]-(2-chloro)-5′-N-ethylcarboxamido-adenosines (24-43) has been synthesised and tested in binding assays at hA1, hA2A and hA3 adenosine receptors, and in a functional assay at the hA2B subtype. The examined compounds displayed high potency in activating A2B receptors with good selectivity versus A2A subtypes. The introduction of an unsubstituted 4-[(phenylcarbamoyl)-methoxy]-phenyl chain at the N6 position of 5′-N-ethylcarboxamido-adenosine led us to the recognition of compound 24 as a full agonist displaying the highest efficacy of the series (EC50 hA2B = 7.3 nM). These compounds represent the first report about adenosine-related structures capable of activating hA2B subtype in the low nanomolar range.

Acetamides and benzamides that are useful in treating sexual dysfunction

The present invention relates to the use of compounds of formula (I) for the treatment of sexual dysfunction and to compositions containing compounds of formula (I) for the treatment of sexual dysfunction.

Acetamides and benzamides that are useful in treating sexual dysfunction

The present invention relates to the use of compounds of formula (I) for the treatment of sexual dysfunction and to compositions containing compounds of formula (I) for the treatment of sexual dysfunction.