66933-68-4

Usage

Uses

Used in Medicinal Chemistry:
4-(4-Morpholinyl)-picolinic acid is used as a building block in the synthesis of pharmaceuticals for its unique structural features that may contribute to the development of new drugs with specific biological activities.
Used in Drug Development:
As a compound with potential biological activity, 4-(4-Morpholinyl)-picolinic acid is used in drug development to explore its efficacy as a pharmaceutical agent, possibly leading to the creation of novel therapeutics.
Used in Research and Development:
In the scientific community, 4-(4-Morpholinyl)-picolinic acid is utilized as a subject of research to better understand its properties, interactions with biological systems, and its potential role in the treatment or management of various diseases.
Used in Chemical Synthesis:
4-(4-Morpholinyl)-picolinic acid is employed as an intermediate in the synthesis of complex organic compounds, particularly those with potential applications in the pharmaceutical and chemical industries.

InChI:InChI=1/C10H12N2O3/c13-10(14)9-7-8(1-2-11-9)12-3-5-15-6-4-12/h1-2,7H,3-6H2,(H,13,14)

Upstream product

• 67-56-1 methanol 
• 82776-75-8 N-Cyclopentyl-N-(4-morpholin-4-yl-pyridine-2-carbonyl)-benzamide 
• 83728-67-0 methyl 2-(morpholin-4-yl)pyridine-4-carboxylate 
• 5470-22-4 4-chloropicolinic acid 
• 24484-93-3 4-Chloro-pyridine-2-carboxylic acid methyl ester 
• 110-91-8 morpholine 

Downstream Products

• 66933-51-5 4-morpholin-4-yl-pyridine-2-carboxylic acid 4-methyl-anilide 
• 66933-49-1 4-morpholin-4-yl-pyridine-2-carboxylic acid anilide 
• 83728-57-8 N-(4-Morpholin-4-yl-pyridine-2-carbonyl)-N-p-tolyl-benzamide 
• 82776-74-7 N-(4-Morpholin-4-yl-pyridine-2-carbonyl)-N-pyridin-2-yl-benzamide 
• 82776-75-8 N-Cyclopentyl-N-(4-morpholin-4-yl-pyridine-2-carbonyl)-benzamide 
• 66933-61-7 4-morpholin-4-yl-N-(4-nitro-phenyl)-pyridine-2-carboximidoyl chloride 
• 72788-04-6 4-morpholin-4-yl-pyridine-2-carboxylic acid N-benzoyl-anilide 
• 66933-50-4 4-morpholin-4-yl-pyridine-2-carboxylic acid 4-nitro-anilide 
• 72788-07-9 4-morpholin-4-yl-pyridine-2-carboxylic acid benzoyl-naphthalen-1-yl-amide 

Relevant academic research and scientific papers

PROTEIN KINASE INHIBITORS AND METHODS OF TREATMENT

The present invention relates to chemical compounds of formula (I) and methods for their use and preparation. In particular, the invention relates to substituted pyrazolo[3,4-d]pyrimidine based compounds which can be used in treating proliferative disorders, use of these compounds in methods of therapy and the manufacture of medicaments as well as compositions containing these compounds.

Potential Acyl-transfer Agents. Reactions of N-Acyl-2-pyridinecarboxamides with Nucleophiles

A fast reaction is obserwed between a series of N-acyl-2-pyridinecarboxamides and cyclopentylamine or pyrrolidine.Most of the acylamides react exclusively at the pyridine-2-carbonyl group.The selectivity of these reactions is explained by the reaction of the pyridine-nitrogen as a base towards the external nucleophile in a five-ring transition state.The acylamides undergo slow reactions with 4-methylaniline, methanol or water.Several reaction paths are observed with these less reactive nucleophiles.An intramolecular acyl group transfer prior to the reaction with an external nucleophile is indicated for three of the N-acylamides which have an N,N-dialkylamino substituent in the pyridine-4-position.Nucleophilic attack occurs predominantly at the N-acyl group of these three compounds which are moderately active acyl-transfer agents.