66949-73-3

Basic information

• Product Name: ethyl N-salicylideneglycinate
• Synonyms: ethyl N-salicylideneglycinate
• CAS NO: 66949-73-3
• Molecular Weight: 207.229
• Mol File: 66949-73-3.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: ethyl N-salicylideneglycinate(CAS DataBase Reference)
• NIST Chemistry Reference: ethyl N-salicylideneglycinate(66949-73-3)
• EPA Substance Registry System: ethyl N-salicylideneglycinate(66949-73-3)

Safety Data

• Hazardous Substances Data: 66949-73-3(Hazardous Substances Data)

Upstream product

• 623-33-6 glycine ethyl ester hydrochloride 
• 90-02-8 salicylaldehyde 
• 459-73-4 GlyOEt*HCl 

Downstream Products

• 57938-78-0 N-(2-hydroxybenzyl)glycine ethyl ester 
• 1635-31-0 aminocoumarine 
• 886-08-8 N-(benzyl)salicylaldimine 

Relevant articles and documents

Platinum(II) complexes of reduced amino acid ester Schiff bases: Synthesis, characterization, and antitumor activity

A series of platinum(II) complexes of reduced amino acid esters Schiff bases were synthesized as potential anticancer agents and characterized by 1H NMR, EA, IR, and molar conductivity. These compounds were tested for their DNA interaction with salmon sperm DNA by ultraviolet spectrum and CD spectrum, and their in vitro anticancer activities have been validated against HL-60, KB, BGC-823, and Bel-7402 cell lines by MTT assay. The cytotoxicity of complexes 5d and 5f are better than cisplatin against Bel-7402 cell lines, and show a close cytotoxic effect against HL-60 cell line.

Synthesis of substituted 3-aminocoumarins from ethyl N-2- hydroxyarylideneglycinates

3-Aminocoumarin and its derivatives are prepared by a thermal (150- 170°C) conversion reaction on the corresponding ethyl N-2- hydroxyarylideneglycinates,[2-HOC6H3(X)CH=NCH2CO2C2Hs; X = H, 5-Br, 5- OH, 5-NO2, 3-OMe, 4-OMe, and 5,6-benzo], which are synthesized by condensing ethyl glycinate hydrochloride with substituted salicylaldehyde.