66950-88-7Relevant academic research and scientific papers
γ-Functionalised β-methylene organolithium compounds from 3-chloro-2-(chloromethyl)propene: Synthetic applications
Ramon,Yus
, p. 10103 - 10110 (1993)
The reaction of functionalised methallylic chlorides 1 with an excess of lithium powder and a catalytic amount of naphthalene (8 mol%) in the presence of a carbonyl compound (Barbier-type conditions) at -78°C leads, after hydrolysis with water, to the corresponding polyfunctionalised compounds 2. Starting materials 1 are easily available from 3-chloro-2-(chloromethyl)propene by nucleophilic substitution.
