66957-65-1Relevant academic research and scientific papers
Synthesis of novel HIV-1 protease inhibitors based on carbohydrate scaffolds
Murphy, Paul V.,O'Brien, Julie L.,Gorey-Feret, Lorraine J.,Smith III, Amos B.
, p. 2259 - 2271 (2007/10/03)
The synthesis of peptidomimetic inhibitors of HIV-1 protease based on 6-deoxy-6-amino-β-D-glucopyranoside and 6-deoxy-6-amino-β-D-mannopyranoside scaffolds has been achieved. The inhibitors had IC50 values in the micromolar range. The results provide a platform for the development of more potent carbohydrate based inhibitors of HIV-1 and other aspartic proteases.
