66957-73-1Relevant articles and documents
Synthesis of new quaternary ammonium salts - Derivatives of phenyl glucopyranosides
Dmochowska,Pellowska-Januszek,Skorupa,Nowacki,Stock,Stepnowski,Wisniewski
, p. 1513 - 1521 (2008/02/04)
A new series of quaternary ammonium tosylates - derivatives of phenyl β-D-glucopyranoside - has been produced in reactions of phenyl 2,3,4-tri-O-acetyl-6-O-tosyl-β-D-glucopyranoside with triethylamine, trimethylamine, 4-(N,N-dimethylamino)pyridine, 2-meth
Synthesis of novel HIV-1 protease inhibitors based on carbohydrate scaffolds
Murphy, Paul V.,O'Brien, Julie L.,Gorey-Feret, Lorraine J.,Smith III, Amos B.
, p. 2259 - 2271 (2007/10/03)
The synthesis of peptidomimetic inhibitors of HIV-1 protease based on 6-deoxy-6-amino-β-D-glucopyranoside and 6-deoxy-6-amino-β-D-mannopyranoside scaffolds has been achieved. The inhibitors had IC50 values in the micromolar range. The results provide a platform for the development of more potent carbohydrate based inhibitors of HIV-1 and other aspartic proteases.