6697-60-5

Basic information

• Product Name: 5-HYDROXY-3'-METHOXYFLAVONE
• Synonyms: 5-HYDROXY-3'-METHOXYFLAVONE;5-HYDROXY-2-(3-METHOXYPHENYL)-4H-CHROMEN-4-ONE
• CAS NO: 6697-60-5
• Molecular Formula: C₁₆H₁₂O₄
• Molecular Weight: 268.26
• Mol File: 6697-60-5.mol
• Article Data: 1

Chemical Properties

• Melting Point: 145-148 °C(Solv: ethanol (64-17-5))
• Boiling Point: 465.0±45.0 °C(Predicted)
• Appearance: /
• Density: 1.329±0.06 g/cm3(Predicted)
• PKA: 6.77±0.40(Predicted)
• CAS DataBase Reference: 5-HYDROXY-3'-METHOXYFLAVONE(CAS DataBase Reference)
• NIST Chemistry Reference: 5-HYDROXY-3'-METHOXYFLAVONE(6697-60-5)
• EPA Substance Registry System: 5-HYDROXY-3'-METHOXYFLAVONE(6697-60-5)

Safety Data

• Hazard Codes: Xn
• Statements: 22
• Hazardous Substances Data: 6697-60-5(Hazardous Substances Data)

Upstream product

• 6665-68-5 5,3’-dihydroxyfIavone 
• 77-78-1 dimethyl sulfate 
• 699-83-2 2,6-dihydroxylacetophenone 
• 78646-28-3 2′-hydroxy-6′-methoxymethoxyacetophenone 

Downstream Products

• 6697-64-9 5-acetoxy-2-(3-methoxy-phenyl)-chromen-4-one 

Relevant articles and documents

Synthesis and biological evaluations of chalcones, flavones and chromenes as farnesoid x receptor (FXR) antagonists

Farnesoid X receptor (FXR), a nuclear receptor mainly distributed in liver and intestine, has been regarded as a potential target for the treatment of various metabolic diseases, cancer and infectious diseases related to liver. Starting from two previously identified chalcone-based FXR antagonists, we tried to increase the activity through the design and synthesis of a library containing chalcones, flavones and chromenes, based on substitution manipulation and conformation (ring closure) restriction strategy. Many chalcones and four chromenes were identified as microM potent FXR antagonists, among which chromene 11c significantly decreased the plasma and hepatic triglyceride level in KKay mice.