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Upstream product

• 934-32-7 1H-benzimidazol-2-amine 
• 504-02-9 1,3-cylohexanedione 
• 123-11-5 4-methoxy-benzaldehyde 

Relevant academic research and scientific papers

Facile DES-mediated synthesis and antioxidant potency of benzimidazoquinazolinone motifs

Abstract: One-pot multicomponent synthesis of benzimidazoquinazolinone scaffolds was achieved by reaction between 2-aminobenzimidazole, aldehyde, and 1,3-cyclohexadione in choline chloride:glycerol as deep eutectic solvent (DES). The developed methodology offers mild and faster reaction conditions with excellent product yield. The synthesized compounds were screened for their antioxidant potency using 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical scavenging, ferric reducing antioxidant power (FRAP), 2,2′-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS), and metal chelating assay. Most of the compounds were found to exhibit good to comparable antioxidant activity with respect to standards. Use of this inexpensive and biodegradable solvent makes this methodology a greener approach compared with other methods reported in literature. Graphical Abstract: Greener, one-pot multicomponent synthesis of benzimidazoquinazolinone scaffolds using DES (ChCl:glycerol) as efficient, recyclable, and biodegradable solvent has been achieved. The synthesized compounds show good to comparable antioxidant activity compared with standards.[Figure not available: see fulltext.]

A new type of SO3H-functionalized magnetic-titania as a robust magnetically-recoverable solid acid nanocatalyst for multi-component reactions

SO3H-functionalized magnetic-titania nanoparticles (Fe3O4@TDI@TiO2-SO3H) have been synthesized by a two-step procedure, involving the covalent grafting of n-TiO2 to n-Fe3O4via 2,4-toluene diisocyanate as a regioselective linker (n-Fe3O4@TDI@TiO2) and subsequent sulfonation using chlorosulfonic acid. The as-prepared nanocatalyst was characterized by Fourier transform infrared spectroscopy (FT-IR), thermogravimetric analysis (TGA), X-ray diffraction (XRD), field emission scanning electron microscopy (FE-SEM) and vibrating sample magnetometry (VSM). The catalytic activity of the nanocatalyst was assessed for the synthesis of benzimidazoquinazolinones and polyhydroquinolines, in which the reaction conditions were optimized by applying central composite design (CCD) through response surface methodology. The nanocatalyst could be separated from the reaction mixture easily by magnetic decantation and reused at least six times without a noticeable degradation in catalytic activity. To the best of our knowledge, there are no literature reports on applying experimental design to optimize the reaction conditions for benzimidazoquinazolinones synthesis.

Green and high efficient synthesis of triaza-benzo[b]fluoren-6-one derivatives in water under microwave irradiation

(Chemical Equation Presented) Triaza-benzo[b]fluoren-6-one derivatives were synthesized via the three-component reaction of aldehyde, cyclohexane-1,3-dione compound and 2-aminobenzimidazole in water under microwave irradiation. The new protocol has the advantages of excellent yield, low cost, reduced environment impact, wide scope and convenient procedure.