669737-86-4 Usage
Description
1-(2,4-Dichlorobenzyl)-1H-pyrrole-2-carbaldehyde, also known as DCBC, is a chemical compound belonging to the pyrrole class of organic compounds. It is characterized by an aromatic benzene ring with two chlorine atoms substituted at the 2 and 4 positions, a pyrrole ring, and an aldehyde functional group. DCBC is recognized for its long-lasting antimicrobial properties and is effective against a broad spectrum of bacteria and fungi.
Uses
Used in Consumer Products:
1-(2,4-Dichlorobenzyl)-1H-pyrrole-2-carbaldehyde is used as an antimicrobial agent in various consumer products for its ability to effectively combat a wide range of bacteria and fungi. This application helps maintain cleanliness and reduce the risk of infections.
Used in Medical Products:
In the medical industry, 1-(2,4-Dichlorobenzyl)-1H-pyrrole-2-carbaldehyde is used as an antimicrobial agent in products such as mouthwashes and toothpaste. Its long-lasting properties contribute to oral hygiene and help prevent dental issues caused by bacterial and fungal infections.
Used in Pharmaceuticals:
1-(2,4-Dichlorobenzyl)-1H-pyrrole-2-carbaldehyde is also utilized in the pharmaceutical industry as an antimicrobial agent. It is incorporated into medications to prevent the growth of harmful microorganisms, ensuring the safety and efficacy of the drugs.
Check Digit Verification of cas no
The CAS Registry Mumber 669737-86-4 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 6,6,9,7,3 and 7 respectively; the second part has 2 digits, 8 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 669737-86:
(8*6)+(7*6)+(6*9)+(5*7)+(4*3)+(3*7)+(2*8)+(1*6)=234
234 % 10 = 4
So 669737-86-4 is a valid CAS Registry Number.
669737-86-4Relevant articles and documents
6-(1-benzyl-1 h -pyrrol-2-yl)-2,4-dioxo-5-hexenoic acids as dual inhibitors of recombinant HIV-1 integrase and ribonuclease H, synthesized by a parallel synthesis approach
Costi, Roberta,Métifiot, Mathieu,Esposito, Francesca,Cuzzucoli Crucitti, Giuliana,Pescatori, Luca,Messore, Antonella,Scipione, Luigi,Tortorella, Silvano,Zinzula, Luca,Novellino, Ettore,Pommier, Yves,Tramontano, Enzo,Marchand, Christophe,Di Santo, Roberto
, p. 8588 - 8598 (2013/12/04)
The increasing efficiency of HAART has helped to transform HIV/AIDS into a chronic disease. Still, resistance and drug-drug interactions warrant the development of new anti-HIV agents. We previously discovered hit 6, active against HIV-1 replication and targeting RNase H in vitro. Because of its diketo-acid moiety, we speculated that this chemotype could serve to develop dual inhibitors of both RNase H and integrase. Here, we describe a new series of 1-benzyl-pyrrolyl diketohexenoic derivatives, 7a-y and 8a-y, synthesized following a parallel solution-phase approach. Those 50 analogues have been tested on recombinant enzymes (RNase H and integrase) and in cell-based assays. Approximately half (22) exibited inhibition of HIV replication. Compounds 7b, 7u, and 8g were the most active against the RNase H activity of reverse-transcriptase, with IC50 values of 3, 3, and 2.5 μM, respectively. Compound 8g was also the most potent integrase inhibitor with an IC50 value of 26 nM.
